氟硝西泮与地西泮预防局部麻醉药诱发惊厥的比较。
A comparison of flunitrazepam and diazepam in the prevention of local anesthetic-induced convulsions.
作者信息
Vatashsky E, Zaroura S, Aronson H B
出版信息
Isr J Med Sci. 1983 Mar;19(3):256-9.
The anticonvulsive effects of equivalent strengths (ED50) of flunitrazepam and diazepam were compared in 60 Sabra mice injected i.p. with median convulsive (CD50) doses of lidocaine or bupivacaine. Convulsions occurred in 40% of those pretreated with diazepam but were completely prevented in those injected with flunitrazepam. Mortality was much higher in those mice pretreated with diazepam, three having died after the administration of lidocaine and four after bupivacaine. With flunitrazepam pretreatment, there were no deaths after lidocaine and only one after bupivacaine. Flunitrazepam protected these mice against local anesthetic-induced convulsions more effectively than did diazepam.
将氟硝西泮和地西泮等效强度（半数有效剂量，ED50）的抗惊厥作用在60只经腹腔注射利多卡因或布比卡因半数惊厥剂量（CD50）的沙地鼠中进行了比较。接受地西泮预处理的动物中有40%发生惊厥，但接受氟硝西泮注射的动物惊厥完全得到预防。接受地西泮预处理的小鼠死亡率更高，三只在注射利多卡因后死亡，四只在注射布比卡因后死亡。经氟硝西泮预处理后，注射利多卡因后无死亡，注射布比卡因后仅一只死亡。氟硝西泮比地西泮更有效地保护这些小鼠免受局部麻醉药诱导的惊厥。
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