Fuller R W, Collier J G
J Pharm Pharmacol. 1983 May;35(5):289-92. doi: 10.1111/j.2042-7158.1983.tb02936.x.
The plasma concentration of sodium cromoglycate (SCG) was measured in four healthy subjects by radioimmunoassay after a 4 mg intravenous dose and after inhaling from 20 mg capsules, and from 10 and 30 mg ml-1 nebulizer solutions. The mean absorption constant (K1) after inhalation was 0.43 h-1. The mean elimination constant from the plasma (Kelim) after intravenous administration was 11.5 h-1, and that after inhalation was similar. The apparent volume of distribution of SCG (Vd beta) was 0.2 litre kg-1 and the mean plasma clearance was 0.35 litre h-1kg-1. The amount of SCG absorbed after inhalation varied according to the method of inhalation and dose. After the inhalation of powder from 20 mg capsules, 1.30-3.96 mg reached the plasma, after inhalation of SCG produced by nebulizing a 10 mg ml-1 solution for 5 min at 10 psi using a Minineb nebulizer 0.19-0.31 mg reached the plasma and when the solution was increased to 30 mg ml-1 the figure was 0.33-0.45 mg.
通过放射免疫分析法，对4名健康受试者进行了如下测定：静脉注射4毫克色甘酸钠（SCG）后，以及从20毫克胶囊吸入后，还有从10毫克/毫升和30毫克/毫升的雾化溶液吸入后血浆中色甘酸钠的浓度。吸入后的平均吸收常数（K1）为0.43 h⁻¹。静脉给药后血浆中的平均消除常数（Kelim）为11.5 h⁻¹，吸入后的情况与之相似。色甘酸钠的表观分布容积（Vdβ）为0.2升/千克，平均血浆清除率为0.35升/小时/千克。吸入后色甘酸钠的吸收量因吸入方法和剂量而异。从20毫克胶囊吸入粉末后，有1.30 - 3.96毫克进入血浆；使用Minineb雾化器在10磅力/平方英寸压力下将10毫克/毫升溶液雾化5分钟后吸入色甘酸钠，有0.19 - 0.31毫克进入血浆；当溶液浓度增加到30毫克/毫升时，这一数值为0.33 - 0.45毫克。
