Yahav Y, Dany S, Katznelson D, Farfel Z
Harry Shwachman Clinic, Department of Pediatrics A, Tel-Hashomer, Israel.
Arch Dis Child. 1988 Jun;63(6):592-7. doi: 10.1136/adc.63.6.592.
The clinical response to sodium cromoglycate treatment was compared with its concentration in serum. Twenty five children with asthma entered a 10 week trial of two baseline weeks followed by eight weeks of treatment by the inhalation of 20 mg of sodium cromoglycate spincaps four times a day. Individual clinical response was determined by the differences between baseline and treatment periods of: (a) percentage of symptomless days (delta score 0); (b) diary derived daily score for four symptoms (delta DS); and (c) peak expiratory flow rate (delta PEFR). At the end of the treatment period, patients inhaled a 20 mg spincap of sodium cromoglycate and the technique of inhalation was graded. Concentrations of sodium cromoglycate in serum were measured by radioimmunoassay in samples withdrawn 5 to 120 minutes after inhalation. Delta Score 0, delta DS, and delta PEFR correlated significantly with the area under the concentration time curve. Both the area under the sodium cromoglycate concentration time curve and clinical response correlated significantly with inhalation technique score. We suggest that response of children with asthma to inhalation treatment with sodium cromoglycate is correlated to its serum concentrations.
将色甘酸钠治疗的临床反应与其血清浓度进行了比较。25名哮喘儿童进入了一项为期10周的试验，前两周为基线期，随后八周通过每天四次吸入20毫克色甘酸钠旋帽进行治疗。个体临床反应由基线期和治疗期之间的差异确定：(a)无症状天数的百分比（差值分数为0）；(b)由日记得出的四种症状的每日分数（差值DS）；以及(c)呼气峰值流速（差值PEFR）。在治疗期结束时，患者吸入一个20毫克的色甘酸钠旋帽，并对吸入技术进行评分。在吸入后5至120分钟采集的样本中，通过放射免疫测定法测量血清中的色甘酸钠浓度。差值分数为0、差值DS和差值PEFR与浓度-时间曲线下面积显著相关。色甘酸钠浓度-时间曲线下面积和临床反应均与吸入技术评分显著相关。我们认为哮喘儿童对色甘酸钠吸入治疗的反应与其血清浓度相关。
