Steffenrud S
Biochem Med. 1984 Oct;32(2):161-80. doi: 10.1016/0006-2944(84)90070-x.
Tritium-labeled 16,16-dimethyl-PGE2 and 9-methylene-PGE2 were incubated with the guinea pig liver mitochondrial fraction. The tetranor and dinor metabolites were obtained, a large portion of the latter contained a saturated carboxyl side chain. Also the beta-hydroxydinor metabolites, analogous to the beta oxidation of fatty acids, were identified. Such metabolites have not been reported earlier in connection with beta oxidation of prostaglandins or prostaglandin analogs. Furthermore, omega-hydroxylated analogs were incubated with the guinea pig liver mitochondrial fraction and were found to pass through beta oxidation to a certain extent.
将氚标记的16,16-二甲基前列腺素E2和9-亚甲基前列腺素E2与豚鼠肝脏线粒体部分一起孵育。获得了四降和二降代谢产物，后者的很大一部分含有饱和羧基侧链。还鉴定出了类似于脂肪酸β氧化的β-羟基二降代谢产物。关于前列腺素或前列腺素类似物的β氧化，此类代谢产物此前尚未见报道。此外，ω-羟基化类似物与豚鼠肝脏线粒体部分一起孵育，发现它们在一定程度上会经历β氧化。
