Houssaint E, Toraño A, Ivanyi J
Eur J Immunol. 1983 Jul;13(7):590-5. doi: 10.1002/eji.1830130715.
The capacity of hemopoietic precursor cells (HPC) to home to embryonic bursal and thymic grafts was investigated in embryonic and newly hatched chickens. Whereas thymic grafts developed normal histogenesis in both types of recipients, the bursal rudiment was colonized and developed in embryonic, but not in newly hatched hosts. In the latter, noncolonized bursal grafts developed neither lymphoid follicles nor granulopoiesis in the mesenchyme. These results are interpreted in terms of ontogenic "maturation" of the HPC which lose their homing potential towards the bursa while they preserve their thymic seeding capacity. This hypothesis is consistent with previously reported data which indicated cyclic continuous recruitment of the thymic lymphoid population, but restricted bursal colonization to a relatively brief period of embryonic life.
在胚胎期和新孵出的雏鸡中，研究了造血前体细胞（HPC）归巢至胚胎法氏囊和胸腺移植物的能力。尽管胸腺移植物在两种类型的受体中都发育出正常的组织发生，但法氏囊原基在胚胎受体中被定植并发育，而在新孵出的受体中则不然。在后者中，未被定植的法氏囊移植物在间充质中既不发育淋巴滤泡也不进行粒细胞生成。这些结果根据HPC的个体发育“成熟”来解释，即HPC失去了归巢至法氏囊的潜力，而保留了其胸腺播种能力。这一假设与先前报道的数据一致，这些数据表明胸腺淋巴细胞群体呈周期性持续补充，但法氏囊定植仅限于胚胎生命中相对较短的时期。
