Ferrier I N, Roberts G W, Crow T J, Johnstone E C, Owens D G, Lee Y C, O'Shaughnessy D, Adrian T E, Polak J M, Bloom S R
Life Sci. 1983 Aug 1;33(5):475-82. doi: 10.1016/0024-3205(83)90797-x.
Cholecystokinin-like immunoreactivity (CCK) and somatostatin-like immunoreactivity (SRIF) were determined in fourteen brains from patients dying with a diagnosis of schizophrenia and in twelve brains from control cases. The schizophrenics had been rated during life and were divided into two groups on the basis of the presence or absence of negative symptoms (affective flattening and poverty of speech). CCK was reduced in temporal cortex of the schizophrenics and in hippocampus and amygdala of those patients with negative symptoms. SRIF was reduced in the hippocampus in samples from the latter group. The selectivity of these changes to limbic lobe may reflect the presence of a degenerative process in that area. The association of changes in hippocampus and amygdala with negative symptoms of schizophrenia suggests a separate mechanism underlying these symptoms.
对14例诊断为精神分裂症死亡患者的大脑和12例对照病例的大脑进行了胆囊收缩素样免疫反应（CCK）和生长抑素样免疫反应（SRIF）测定。这些精神分裂症患者生前已被评级，并根据是否存在阴性症状（情感平淡和言语贫乏）分为两组。精神分裂症患者颞叶皮质以及有阴性症状患者的海马体和杏仁核中的CCK减少。后一组样本中海马体中的SRIF减少。这些变化对边缘叶的选择性可能反映了该区域存在退行性过程。海马体和杏仁核的变化与精神分裂症阴性症状的关联表明这些症状存在单独的机制。
