Burnett J W, Calton G J
Med J Aust. 1983 Aug 20;2(4):192-4.
Verapamil, a calcium antagonist, has been shown to be effective in delaying death in mice after intravenous challenge with box-jellyfish (Chironex fleckeri) venom. Death from a challenge of up to three mouse-lethal doses of venom was significantly delayed after the prior intravenous administration of verapamil (P = 0.003). A smaller dose of verapamil could "rescue" mice previously envenomed with 1.25 mouse-lethal doses (P = 0.0001). These data suggest that verapamil injections should be added to the first-aid procedures performed on the beach for victims of box-jellyfish stings.
维拉帕米是一种钙拮抗剂，已证明其在小鼠经箱形水母（ Chironex fleckeri ）毒液静脉注射攻击后可有效延缓死亡。在预先静脉注射维拉帕米后，高达三个小鼠致死剂量的毒液攻击所致的死亡显著延迟（P = 0.003）。较小剂量的维拉帕米能够 “挽救” 先前被1.25个小鼠致死剂量毒液蜇伤的小鼠（P = 0.0001）。这些数据表明，对于箱形水母蜇伤的受害者，应将维拉帕米注射添加到在海滩上进行的急救程序中。
