Tibballs J, Williams D, Sutherland S K
Internsive Care Unit, Royal Children's Hospital, Melbourne, Victoria.
Anaesth Intensive Care. 1998 Feb;26(1):40-5. doi: 10.1177/0310057X9802600105.
The efficacy of antivenom and verapamil against Chironex fleckeri (box jellyfish) venom was investigated in monitored mechanically ventilated piglets. Chironex fleckeri tentacle extract alone, a mixture of tentacle extract with antivenom, and verapamil before tentacle extract were administered intravenously to groups of animals. Tentacle extract caused severe systemic hypotension, cardiac dysrrhythmias, pulmonary hypertension, haemolysis and hyperkalaemia. These effects were prevented by pre-incubation of tentacle extract with antivenom. Verapamil did not prevent any effect of venom, exacerbated cardiovascular collapse and increased mortality. We conclude that antivenom neutralizes the cardiovascular, haemolytic and hyperkalaemic effects of box jellyfish venom. Verapamil does not prevent any of these effects and is contra-indicated for treatment of envenomation.
在接受机械通气监测的仔猪中研究了抗蛇毒血清和维拉帕米对箱形水母（Chironex fleckeri）毒液的疗效。将单独的箱形水母触手提取物、触手提取物与抗蛇毒血清的混合物以及在给予触手提取物之前的维拉帕米静脉注射给几组动物。触手提取物可导致严重的全身性低血压、心律失常、肺动脉高压、溶血和高钾血症。抗蛇毒血清与触手提取物预孵育可预防这些效应。维拉帕米不能预防毒液的任何效应，反而会加重心血管衰竭并增加死亡率。我们得出结论，抗蛇毒血清可中和箱形水母毒液的心血管、溶血和高钾血症效应。维拉帕米不能预防这些效应中的任何一种，且禁忌用于治疗中毒。
