Filby A B, Gross D S
Cell Tissue Res. 1983;233(1):69-80. doi: 10.1007/BF00222233.
Immunocytochemical methods were used to compare the localization of somatostatin (SRIF) in the human and rhesus monkey hypothalamus. The distribution of SRIF-containing cell bodies and fibers is similar in the two species. Perikarya are located predominantly in the periventricular region and to a lesser extent in the ventromedial nucleus. Fibers occur in dense clusters within the periventricular region, ventromedial nucleus, arcuate nucleus, median eminence, and pericommissural area of both species. Analysis of serial sections suggests that fibers originate from cells in the periventricular region, extend ventrally through the ventromedial and arcuate nuclei to terminate around the portal vessels of the infundibular stalk, and thereby participate in the regulation of anterior pituitary function. Somatostatinergic fibers are also found surrounding non-immunoreactive perikarya in the ventromedial nucleus and periventricular region of both primates. This arrangement may support somatostatin's postulated role as a neurotransmitter or neuromodulator. The strong similarity between the localization of hypothalamic SRIF in the human and rhesus monkey supports the use of the rhesus monkey as a model for the study of somatostatin as a neuroendocrine regulatory in the human.
采用免疫细胞化学方法比较生长抑素（SRIF）在人和恒河猴下丘脑的定位。含SRIF的细胞体和纤维的分布在这两个物种中相似。胞体主要位于室周区域，在腹内侧核中分布较少。纤维在两个物种的室周区域、腹内侧核、弓状核、正中隆起和连合周区域内密集分布。连续切片分析表明，纤维起源于室周区域的细胞，向腹侧延伸穿过腹内侧核和弓状核，终止于漏斗柄的门静脉周围，从而参与垂体前叶功能的调节。在两种灵长类动物的腹内侧核和室周区域，生长抑素能纤维也围绕着非免疫反应性胞体分布。这种排列可能支持生长抑素作为神经递质或神经调质的假定作用。人和恒河猴下丘脑SRIF定位的高度相似性支持将恒河猴作为研究生长抑素在人类中作为神经内分泌调节因子的模型。
