Lachnit K S, Proszowski E, Rieder L
Br J Clin Pharmacol. 1983;16 Suppl 1(Suppl 1):173S-177S. doi: 10.1111/j.1365-2125.1983.tb02291.x.
The use of hypnotics in the elderly must be approached with special care in view of possible changes in pharmacokinetic behaviour and drug interactions in older patients. In a randomized, double-blind study in a large geriatric department, midazolam was compared with the barbiturate combination Vesparax with regard to efficacy and safety. The comparison of the efficacy of the 2 hypnotics showed them to be almost identical in this respect. Side-effects, however, were more frequent with Vesparax. Furthermore, in the Vesparax group, unlike in the midazolam group, a troublesome cumulation of effect was observed, together with relatively frequent signs of hangover. It is concluded that, in appropriately titrated dosage, midazolam is an effective and well-tolerated hypnotic for use in the elderly.
鉴于老年患者的药代动力学行为可能发生变化以及存在药物相互作用，在老年患者中使用催眠药必须格外谨慎。在一个大型老年科进行的一项随机双盲研究中，比较了咪达唑仑与巴比妥类药物组合Vesparax的疗效和安全性。这两种催眠药疗效的比较表明，在这方面它们几乎相同。然而，Vesparax的副作用更常见。此外，与咪达唑仑组不同，在Vesparax组中观察到了令人烦恼的效应累积，以及相对频繁的宿醉迹象。得出的结论是，以适当滴定的剂量，咪达唑仑是一种用于老年人的有效且耐受性良好的催眠药。
