Livne P M, Kaplan B, Ovadia Y, Servadio C
Acta Obstet Gynecol Scand. 1983;62(4):337-40. doi: 10.3109/00016348309156234.
Micturition difficulties and urinary retention are common complications after abdominal or vaginal hysterectomy. Adrenergic receptors are located in the bladder neck and proximal urethra, and blocking these receptors with alpha-blockers such as phenoxybenzamine (Dibenzyline) may improve micturition and prevent postoperative urinary retention. In a randomized clinical trial, 51 patients who underwent total abdominal hysterectomy, received a prophylactic dose of Dibenzyline 10 micrograms orally 6-8 hours after operation and again the next day about 18 hours later. Only 2 of the 51 patients were found to have urinary retention, in comparison with 9 of 48 patients in the control group (p less than 0.05). Another group of patients who underwent vaginal hysterectomy were treated according to the same protocol. Eight of the 30 patients in this study group required catheterization to drain the overdistended bladder, in comparison with 16 of 26 patients in the control group (p less than 0.025). It seems from this clinical trial that prophylactic treatment with Dibenzyline is recommended after abdominal hysterectomy or vaginal operation in order to improve micturition and prevent urinary retention.
排尿困难和尿潴留是腹部或阴道子宫切除术后常见的并发症。肾上腺素能受体位于膀胱颈和尿道近端，使用酚苄明（苯苄胺）等α受体阻滞剂阻断这些受体可能会改善排尿并预防术后尿潴留。在一项随机临床试验中，51例行全腹子宫切除术的患者在术后6 - 8小时口服10微克预防性剂量的苯苄胺，次日约18小时后再次服用。51例患者中仅2例出现尿潴留，而对照组48例患者中有9例出现尿潴留（p<0.05）。另一组行阴道子宫切除术的患者按照相同方案进行治疗。该研究组30例患者中有8例需要插管引流过度膨胀的膀胱，而对照组26例患者中有16例需要插管（p<0.025）。从这项临床试验来看，似乎建议在腹部子宫切除术或阴道手术后使用苯苄胺进行预防性治疗，以改善排尿并预防尿潴留。
