Kekcheeva N G, Vovk O A, Chereshkova E A, Abrosimova G E
Acta Virol. 1983 May;27(3):268-72.
The susceptibility of cotton rat macrophages to Rickettsia (R.) prowazekii, the percentage of the affected cells, and the intensity of damage to individual cells by rickettsiae were found to be much higher than those in guinea pig macrophages infected under similar conditions. At the same time, cotton rat macrophages proved to be more resistant to the effect of rickettsiae than guinea pig macrophages. Some common features of infection in cell culture and in animals have been observed. It is suggested that the outcome of interaction of rickettsiae with macrophages of one or another animal species may be important in generating acute or persistent infection.
研究发现，棉鼠巨噬细胞对普氏立克次体的易感性、受感染细胞的百分比以及立克次体对单个细胞的损伤强度，均远高于在类似条件下感染的豚鼠巨噬细胞。与此同时，事实证明棉鼠巨噬细胞比豚鼠巨噬细胞对立克次体的作用更具抗性。已观察到细胞培养和动物感染中的一些共同特征。有人提出，立克次体与不同动物物种巨噬细胞相互作用的结果，可能对引发急性或持续性感染具有重要意义。
