Gäde G, Ellington W R
Comp Biochem Physiol A Comp Physiol. 1983;76(3):615-20. doi: 10.1016/0300-9629(83)90463-2.
The hearts of many bivalve and gastropod molluscs are resistant to exposure to hypoxic and anoxic conditions. Glycogen and aspartate are simultaneously fermented leading to the accumulation of alanine, succinate and alanopine/strombine. Lactate is not a major end product of anaerobic metabolism in molluscan hearts. In contrast, vertebrate hearts respond to hypoxia by the fermentation of glycogen leading to lactate formation. There is some evidence for aspartate and glutamate breakdown in vertebrate hearts during anoxia. However, the quantitative contribution of this process to energy production is small. The differences in modes of energy production in molluscan and vertebrate hearts may reflect adaptations to long-term as opposed to short-term anoxia.
许多双壳类和腹足类软体动物的心脏对缺氧和无氧条件具有耐受性。糖原和天冬氨酸同时发酵，导致丙氨酸、琥珀酸和丙氨酸甜菜碱/肌胺的积累。乳酸不是软体动物心脏无氧代谢的主要终产物。相比之下，脊椎动物的心脏通过糖原发酵产生乳酸来应对缺氧。有证据表明，脊椎动物心脏在缺氧期间会分解天冬氨酸和谷氨酸。然而，这一过程对能量产生的定量贡献很小。软体动物和脊椎动物心脏能量产生模式的差异可能反映了对长期而非短期缺氧的适应性。
