利用精子进行人类白细胞抗原（HLA）基因分型：单倍体基因表达的证据
HLA genotyping by using spermatozoa: evidence for haploid gene expression.
作者信息
Arnaiz-Villena A, Festenstein H
出版信息
Lancet. 1976 Oct 2;2(7988):707-9. doi: 10.1016/s0140-6736(76)90005-2.
PMID:61393
Abstract
Serologically defined HLA-A and HLA-B antigens are expressed in a haploid manner on the surface of spermatozoa. This enabled the HLA-genotypes of four men to be determined by using sperm. This technique will mean that the HLA genotype of potential male graft recipients and others can be determined more easily and even when families are not available. These findings also provide strong evidence that some cell products are encoded by a haploid genome.
摘要
血清学定义的HLA - A和HLA - B抗原以单倍体方式表达于精子表面。这使得通过使用精子能够确定四名男性的HLA基因型。这项技术意味着潜在男性移植受者及其他人群的HLA基因型能够更轻松地被确定，甚至在无法获取家族信息时也能做到。这些发现还为某些细胞产物由单倍体基因组编码提供了有力证据。
相似文献
1
HLA genotyping by using spermatozoa: evidence for haploid gene expression.利用精子进行人类白细胞抗原（HLA）基因分型：单倍体基因表达的证据
Lancet. 1976 Oct 2;2(7988):707-9. doi: 10.1016/s0140-6736(76)90005-2.
2
Letter: HLA-D on sperm is haploid, enabling use of sperm for HLA-D typing.信函：精子上的HLA-D是单倍体，这使得精子可用于HLA-D分型。
Lancet. 1975 Dec 20;2(7947):1255-6. doi: 10.1016/s0140-6736(75)92089-9.
3
Selection of haploid spermatozoa and its application to HLA-D typing.单倍体精子的筛选及其在HLA - D分型中的应用。
Scand J Immunol. 1977;6(5):511-4. doi: 10.1111/j.1365-3083.1977.tb02113.x.
4
Haploid expression of HLA genes on spermatozoa I1[letter].精子上HLA基因的单倍型表达I1[信函]
Lancet. 1977 Feb 12;1(8007):363-4. doi: 10.1016/s0140-6736(77)91164-3.
5
The HLA typing of human spermatozoa by two color fluorescence.用双色荧光法对人类精子进行HLA分型
Tissue Antigens. 1982 Jan;19(1):90-1. doi: 10.1111/j.1399-0039.1982.tb01420.x.
6
Sperm-induced lymphocyte activation.精子诱导的淋巴细胞活化。
Lancet. 1978 Apr 29;1(8070):937-8.
7
Three-point association of HLA-A,B,Bf haplotypes deduced in 200 parents of 100 families.在100个家庭的200名父母中推导得出的HLA - A、B、Bf单倍型的三点关联
Scand J Immunol. 1977;6(5):459-64. doi: 10.1111/j.1365-3083.1977.tb02103.x.
8
Letter: HLA and mycosis fungoides.信件：人类白细胞抗原与蕈样肉芽肿
Lancet. 1976 May 29;1(7970):1179. doi: 10.1016/s0140-6736(76)91561-0.
9
HLA-DW3 associated with coeliac disease.HLA - DW3与乳糜泻相关。
Lancet. 1976 Mar 6;1(7958):506-8. doi: 10.1016/s0140-6736(76)90294-4.
10
HLA-D typing of human lymphocytes using frozen and thawed spermatozoa.使用冻融精子对人淋巴细胞进行HLA - D分型
J Immunol Methods. 1979;25(1):31-6. doi: 10.1016/0022-1759(79)90161-3.
引用本文的文献
1
No evidence for MHC class II-based non-random mating at the gametic haplotype in Atlantic salmon.没有证据表明大西洋鲑在配子单倍型上存在基于MHC II类的非随机交配。
Heredity (Edinb). 2017 Jun;118(6):563-567. doi: 10.1038/hdy.2016.129. Epub 2017 Jan 18.
2
On the selective elimination of Y-bearing sperm.Y 染色体精子的选择性排除。
Immunogenetics. 1978 Dec;7(1):13-6. doi: 10.1007/BF01843982.
3
Atlantic salmon eggs favour sperm in competition that have similar major histocompatibility alleles.大西洋鲑鱼卵在竞争中更青睐具有相似主要组织相容性等位基因的精子。
Proc Biol Sci. 2009 Feb 7;276(1656):559-66. doi: 10.1098/rspb.2008.1257.
4
GPLA antigens are not expressed on guinea-pig epididymal spermatozoa.豚鼠附睾精子不表达GPLA抗原。
Clin Exp Immunol. 1984 Sep;57(3):687-93.
5
Evidence for postmeiotic expression of ribosomal RNA genes during male gametogenesis.雄性配子发生过程中核糖体RNA基因减数分裂后表达的证据。
Hum Genet. 1977 Oct 14;38(3):279-84. doi: 10.1007/BF00402153.
6
Immunological observations following vasectomy.输精管切除术后的免疫学观察。
Experientia. 1979 Sep 15;35(9):1243-4. doi: 10.1007/BF01963315.
Zotero 插件