五种昏迷剂量药物对豚鼠脑内神经递质氨基酸的影响。

The effect of five drugs in coma doses on neurotransmitter amino acids in the brains of guinea pigs.

作者信息

Sabato A F, Pala F, Barbi S, Ferraro M, Beccia F

出版信息

Resuscitation. 1983 Aug;10(4):317-20. doi: 10.1016/0300-9572(83)90033-3.

Abstract

The study has been carried out in order to investigate the effects of some drugs in coma doses on the concentration in brain of some amino acids involved in brain function. Six groups of 25 guinea pigs each were utilized. In each of the five groups a subcutaneous dose of diazepam, flunitrazepam, phenobarbital, phenytoin or alfaxalone, was injected and one group was utilized as control. Some neurotransmitter amino acids (glutamate, aspartate, glycine and taurine) and precursors of neurotransmitters (phenylalanine and tyrosine) were determined in brain preparations. The results are discussed.

摘要

开展该研究是为了调查某些处于昏迷剂量的药物对一些参与脑功能的氨基酸在脑内浓度的影响。使用了六组豚鼠，每组25只。在五组中的每组皮下注射了地西泮、氟硝西泮、苯巴比妥、苯妥英或阿法沙龙的剂量，另一组用作对照。在脑制剂中测定了一些神经递质氨基酸（谷氨酸、天冬氨酸、甘氨酸和牛磺酸）以及神经递质的前体（苯丙氨酸和酪氨酸）。对结果进行了讨论。