Herbert M, Standen P J, Short A H, Birmingham A T
Psychopharmacology (Berl). 1983;81(4):335-9. doi: 10.1007/BF00427573.
In a double-blind, balanced crossover study, eight healthy male volunteers ingested either DL-308 (10 mg), DL-308 (20 mg), oxazepam (30 mg) or placebo. Subjective estimates of coordination and anxiety, objective performance measurements and cardiovascular measurements were taken at 1, 3, 5 and 8 h after ingestion. DL-308 (20 mg) exerted a strong sedative effect as judged by self-reported coordination scores and performance on logical reasoning and reaction time tests. The effect was evident almost immediately and, on the coordination and reasoning tests, lasted up to 8 h following ingestion. Attention is drawn to the need to extend performance testing in order to maximise test sensitivity. No drug had any consistent or strong influence on cardiovascular measures.
在一项双盲、均衡交叉研究中，8名健康男性志愿者分别服用了DL - 308（10毫克）、DL - 308（20毫克）、奥沙西泮（30毫克）或安慰剂。在服药后1小时、3小时、5小时和8小时进行了协调性和焦虑的主观评估、客观性能测量以及心血管测量。根据自我报告的协调性得分以及逻辑推理和反应时间测试的表现判断，DL - 308（20毫克）具有很强的镇静作用。这种作用几乎立即显现，并且在协调性和推理测试中，服药后可持续长达8小时。需要注意的是，有必要扩展性能测试以最大限度地提高测试灵敏度。没有任何一种药物对心血管测量有持续或强烈的影响。
