Kerr J S, Hindmarch I, Sherwood N
Robens Institute, Milford Hospital, Godalming, Surrey, UK.
Eur J Clin Pharmacol. 1992;42(5):507-10. doi: 10.1007/BF00314859.
Ten different doses of oxazepam (ranging from 7.5 to 50 mg) or placebo were administered to a total of 28 female subjects in three separate studies. Subjects completed a battery of psychometric tests at 1 and 2 h postdose. The tests included critical flicker fusion, choice reaction time and a tracking task. Following separate analyses of variance, effect sizes (Cohen's d) were calculated for each dose at each dependent variable. These effect sizes were then correlated with the dose of drug administered, using regression analyses. It was found that the doses correlated highly with most of the psychometric variables determined, implying that the test battery is sensitive to drug effects.
