子宫内短期接触酒精的大鼠胎儿的畸形与生长情况

Malformations and growth of rat fetuses exposed to brief periods of alcohol in utero.

作者信息

Fernandez K, Caul W F, Boyd J E, Henderson G I, Michaelis R C

出版信息

Teratog Carcinog Mutagen. 1983;3(6):457-60. doi: 10.1002/1520-6866(1990)3:6<457::aid-tcm1770030602>3.0.co;2-i.

DOI:10.1002/1520-6866(1990)3:6<457::aid-tcm1770030602>3.0.co;2-i

Abstract

The effects of acute alcohol exposure at specific stages of gestation on fetal growth and morphology were investigated in rats. Alcohol was administered by gavage on either days 7-9, 10-12, or 13-15 of gestation (sperm positive, day 0). Increased resorptions and reduced body weights in fetuses were related to prenatal alcohol treatment and were not related to the period of alcohol administration. The teratological examinations did not reveal structural anomalies related to alcohol treatment. These findings are of interest in that they were observed in fetuses treated in an acute model of the fetal alcohol syndrome (FAS) which has shown reductions in protein synthesis.

摘要

研究人员在大鼠中调查了孕期特定阶段急性酒精暴露对胎儿生长和形态的影响。在妊娠第7 - 9天、10 - 12天或13 - 15天（精子阳性为第0天）通过灌胃给予酒精。胎儿吸收增加和体重减轻与产前酒精处理有关，而与酒精给药时期无关。致畸学检查未发现与酒精处理相关的结构异常。这些发现很有意思，因为它们是在胎儿酒精综合征（FAS）急性模型处理的胎儿中观察到的，该模型已显示蛋白质合成减少。