Volgarev A P, Skovikova L P, Ivanova E V
Acta Virol. 1983 Nov;27(6):496-501.
The dynamics of immune cell responsiveness in the process of development of primary and secondary immune responses after infection of adult Syrian hamsters with native respiratory syncytial virus (RSV) was studied. In primary immune response, the enhancement of functional responsiveness of lymphocytes to mitogens and the maximum level of their spontaneous proliferative activity were found to precede the optimal level of antibody synthesis. Regulation of the dynamics of immunogenesis after reinfection of animals showed typical features of the secondary immune response.
研究了成年叙利亚仓鼠感染天然呼吸道合胞病毒（RSV）后，初次和二次免疫反应过程中免疫细胞反应性的动态变化。在初次免疫反应中，发现淋巴细胞对有丝分裂原的功能反应性增强及其自发增殖活性的最高水平先于抗体合成的最佳水平。动物再次感染后免疫发生动态变化的调节表现出二次免疫反应的典型特征。
