一种用于分析DNA中同源编码序列的新规则。

A new rule for analyzing homologous coding sequences in DNA.

作者信息

Paetkau V

出版信息

Nucleic Acids Res. 1984 Jan 11;12(1 Pt 1):159-73. doi: 10.1093/nar/12.1part1.159.

DOI:10.1093/nar/12.1part1.159

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC320993/

Abstract

A new rule is proposed for detecting homology between DNA sequences coding for proteins. Simple coding considerations predict that if two DNA sequences are homologous because of a common ancestry, they should share sequence similarities primarily in the same translation phase, with their codons aligned. Similarities which are in phase are shown to be more frequent between related sequences than between unrelated or random ones. But similar segments which are out of translation phase are no more frequent between related than unrelated sequences. Duplication and concatenation of genetic elements, followed by gene duplication and random mutations would lead to the patterns observed. Similarities are examined between various immunologically important sequences, including immunoglobulins, MHC products, and the T lymphocyte antigen Thy 1.

摘要

提出了一种用于检测编码蛋白质的DNA序列之间同源性的新规则。简单的编码考量预测，如果两个DNA序列由于共同祖先而同源，它们应该主要在相同的翻译阶段共享序列相似性，且密码子对齐。结果表明，相关序列之间同相的相似性比不相关或随机序列之间更常见。但是，非同相的相似片段在相关序列之间并不比不相关序列之间更常见。遗传元件的复制和串联，随后是基因复制和随机突变，将导致观察到的模式。研究了各种免疫重要序列之间的相似性，包括免疫球蛋白、MHC产物和T淋巴细胞抗原Thy 1。

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本文引用的文献

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Proc Natl Acad Sci U S A. 1983 Mar;80(5):1382-6. doi: 10.1073/pnas.80.5.1382.

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Organization of the rat gamma-fibrinogen gene: alternative mRNA splice patterns produce the gamma A and gamma B (gamma ') chains of fibrinogen.大鼠γ-纤维蛋白原基因的组织：可变mRNA剪接模式产生纤维蛋白原的γA和γB（γ'）链。

Cell. 1982 Nov;31(1):159-66. doi: 10.1016/0092-8674(82)90415-9.

6

The amino acid sequence and gene organization of the heavy chain of the HLA-DR antigen: homology to immunoglobulins.HLA - DR抗原重链的氨基酸序列与基因结构：与免疫球蛋白的同源性

Proc Natl Acad Sci U S A. 1982 Oct;79(19):6013-7. doi: 10.1073/pnas.79.19.6013.

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DNA sequence of the gene encoding the E alpha Ia polypeptide of the BALB/c mouse.编码BALB/c小鼠Eα Ia多肽的基因的DNA序列。

Science. 1982 Dec 17;218(4578):1229-32. doi: 10.1126/science.6815800.

8

Alpha chain of HLA-DR transplantation antigens is a member of the same protein superfamily as the immunoglobulins.HLA - DR移植抗原的α链与免疫球蛋白属于同一蛋白质超家族成员。

Cell. 1982 Aug;30(1):153-61. doi: 10.1016/0092-8674(82)90021-6.

9

Organization and evolution of immunoglobulin VH gene subgroups.免疫球蛋白VH基因亚群的组织与进化

Proc Natl Acad Sci U S A. 1982 Jul;79(14):4405-9. doi: 10.1073/pnas.79.14.4405.

10

Identification of the 48-base-long primordial building block sequence of mouse immunoglobulin variable region genes.小鼠免疫球蛋白可变区基因48个碱基长的原始构建模块序列的鉴定。

Proc Natl Acad Sci U S A. 1982 Mar;79(6):1999-2002. doi: 10.1073/pnas.79.6.1999.

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