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1
A new rule for analyzing homologous coding sequences in DNA.一种用于分析DNA中同源编码序列的新规则。
Nucleic Acids Res. 1984 Jan 11;12(1 Pt 1):159-73. doi: 10.1093/nar/12.1part1.159.
2
Polymorphic class II sequences linked to the rat major histocompatibility complex (RT1) homologous to human DR and DQ sequences.与大鼠主要组织相容性复合体（RT1）相关的多态性II类序列，与人DR和DQ序列同源。
J Immunol. 1985 Aug;135(2):1450-5.
3
Isolation of CD1 genes: a family of major histocompatibility complex-related differentiation antigens.CD1基因的分离：一组与主要组织相容性复合体相关的分化抗原。
Proc Natl Acad Sci U S A. 1986 Dec;83(23):9154-8. doi: 10.1073/pnas.83.23.9154.
4
The amino acid sequence and gene organization of the heavy chain of the HLA-DR antigen: homology to immunoglobulins.HLA - DR抗原重链的氨基酸序列与基因结构：与免疫球蛋白的同源性
Proc Natl Acad Sci U S A. 1982 Oct;79(19):6013-7. doi: 10.1073/pnas.79.19.6013.
5
[Analysis, identification and correction of some errors of model refseqs appeared in NCBI Human Gene Database by in silico cloning and experimental verification of novel human genes].[通过新型人类基因的电子克隆和实验验证对NCBI人类基因数据库中出现的模型参考序列的一些错误进行分析、鉴定和校正]
Yi Chuan Xue Bao. 2004 May;31(5):431-43.
6
Relationship of human variable region heavy chain germ-line genes to genes encoding anti-DNA autoantibodies.人类重链可变区胚系基因与编码抗DNA自身抗体的基因之间的关系。
J Immunol. 1987 Oct 1;139(7):2496-501.
7
The human Thy-1 gene: structure and chromosomal location.人类Thy-1基因：结构与染色体定位。
Proc Natl Acad Sci U S A. 1985 Oct;82(19):6657-61. doi: 10.1073/pnas.82.19.6657.
8
Complete sequence of a cloned cDNA encoding rabbit secreted mu-chain of VHa2 allotype: comparisons with VHa1 and membrane mu sequences.编码兔VHa2同种异型分泌型μ链的克隆cDNA的完整序列：与VHa1和膜型μ序列的比较
J Immunol. 1984 Jan;132(1):490-5.
9
The murine Ia alpha chains, E alpha and A alpha, show a surprising degree of sequence homology.小鼠Iaα链，即Eα和Aα，表现出惊人程度的序列同源性。
Proc Natl Acad Sci U S A. 1983 Jan;80(2):534-8. doi: 10.1073/pnas.80.2.534.
10
Structure and genomic organization of a second cluster of immunoglobulin heavy chain gene segments in the channel catfish.斑点叉尾鮰免疫球蛋白重链基因片段第二簇的结构与基因组组织
J Immunol. 1999 Feb 1;162(3):1519-29.

本文引用的文献

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Optimal sequence alignments.最佳序列比对。
Proc Natl Acad Sci U S A. 1983 Mar;80(5):1382-6. doi: 10.1073/pnas.80.5.1382.
2
DNA sequence of a gene encoding a BALB/c mouse Ld transplantation antigen.编码BALB/c小鼠Ld移植抗原的基因的DNA序列。
Science. 1982 Feb 5;215(4533):679-82. doi: 10.1126/science.7058332.
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Major histocompatibility antigens: the human (HLA-A, -B, -C) and murine (H-2K, H-2D) class I molecules.主要组织相容性抗原：人类（HLA - A、- B、- C）和小鼠（H - 2K、H - 2D）I类分子。
Cell. 1981 May;24(2):287-99. doi: 10.1016/0092-8674(81)90318-4.
4
Mouse immunoglobulin D: messenger RNA and genomic DNA sequences.小鼠免疫球蛋白D：信使核糖核酸和基因组脱氧核糖核酸序列。
Science. 1980 Sep 19;209(4463):1353-60. doi: 10.1126/science.6968091.
5
Organization of the rat gamma-fibrinogen gene: alternative mRNA splice patterns produce the gamma A and gamma B (gamma ') chains of fibrinogen.大鼠γ-纤维蛋白原基因的组织：可变mRNA剪接模式产生纤维蛋白原的γA和γB（γ'）链。
Cell. 1982 Nov;31(1):159-66. doi: 10.1016/0092-8674(82)90415-9.
6
The amino acid sequence and gene organization of the heavy chain of the HLA-DR antigen: homology to immunoglobulins.HLA - DR抗原重链的氨基酸序列与基因结构：与免疫球蛋白的同源性
Proc Natl Acad Sci U S A. 1982 Oct;79(19):6013-7. doi: 10.1073/pnas.79.19.6013.
7
DNA sequence of the gene encoding the E alpha Ia polypeptide of the BALB/c mouse.编码BALB/c小鼠Eα Ia多肽的基因的DNA序列。
Science. 1982 Dec 17;218(4578):1229-32. doi: 10.1126/science.6815800.
8
Alpha chain of HLA-DR transplantation antigens is a member of the same protein superfamily as the immunoglobulins.HLA - DR移植抗原的α链与免疫球蛋白属于同一蛋白质超家族成员。
Cell. 1982 Aug;30(1):153-61. doi: 10.1016/0092-8674(82)90021-6.
9
Organization and evolution of immunoglobulin VH gene subgroups.免疫球蛋白VH基因亚群的组织与进化
Proc Natl Acad Sci U S A. 1982 Jul;79(14):4405-9. doi: 10.1073/pnas.79.14.4405.
10
Identification of the 48-base-long primordial building block sequence of mouse immunoglobulin variable region genes.小鼠免疫球蛋白可变区基因48个碱基长的原始构建模块序列的鉴定。
Proc Natl Acad Sci U S A. 1982 Mar;79(6):1999-2002. doi: 10.1073/pnas.79.6.1999.

一种用于分析DNA中同源编码序列的新规则。

A new rule for analyzing homologous coding sequences in DNA.

作者信息

Paetkau V

出版信息

Nucleic Acids Res. 1984 Jan 11;12(1 Pt 1):159-73. doi: 10.1093/nar/12.1part1.159.

DOI:10.1093/nar/12.1part1.159
PMID:6141551
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC320993/
Abstract

A new rule is proposed for detecting homology between DNA sequences coding for proteins. Simple coding considerations predict that if two DNA sequences are homologous because of a common ancestry, they should share sequence similarities primarily in the same translation phase, with their codons aligned. Similarities which are in phase are shown to be more frequent between related sequences than between unrelated or random ones. But similar segments which are out of translation phase are no more frequent between related than unrelated sequences. Duplication and concatenation of genetic elements, followed by gene duplication and random mutations would lead to the patterns observed. Similarities are examined between various immunologically important sequences, including immunoglobulins, MHC products, and the T lymphocyte antigen Thy 1.

摘要

提出了一种用于检测编码蛋白质的DNA序列之间同源性的新规则。简单的编码考量预测，如果两个DNA序列由于共同祖先而同源，它们应该主要在相同的翻译阶段共享序列相似性，且密码子对齐。结果表明，相关序列之间同相的相似性比不相关或随机序列之间更常见。但是，非同相的相似片段在相关序列之间并不比不相关序列之间更常见。遗传元件的复制和串联，随后是基因复制和随机突变，将导致观察到的模式。研究了各种免疫重要序列之间的相似性，包括免疫球蛋白、MHC产物和T淋巴细胞抗原Thy 1。