小鼠免疫球蛋白可变区基因48个碱基长的原始构建模块序列的鉴定。
Identification of the 48-base-long primordial building block sequence of mouse immunoglobulin variable region genes.
作者信息
Ohno S, Matsunaga T, Wallace R B
出版信息
Proc Natl Acad Sci U S A. 1982 Mar;79(6):1999-2002. doi: 10.1073/pnas.79.6.1999.
Abstract
Mouse immunoglobulin heavy-chain variable region (Ig VH) genes apparently arose from the approximately 600-base-pair-long (approximately 12 tandem repeats of the 48-base-pair-long primordial building block sequence TTC-AGC-AGC-CTG-ACT-GGA-TAT-GAC-CTG-GAG-TGG-ACT-TAC-TGC-GCA-AGA) that in the original reading frame specified the amino acid sequence Phe-Ser-Ser-Leu-Thr-Gly-Tyr-Asp-Leu-Glu-Trp-Thr-Tyr-Cys-Ala-Arg. The previously identified, shorter prototype building blocks merely represented particular portions of the above primordial sequence. Even today, the direct descendant in toto of this primordial sequence specifies the last one-sixth of each VH coding sequence: the 83rd to 98th amino acid residues. Furthermore, its four truncated derivatives specify the 4th to 14th, 17th to 23rd, 29th to 37th, and 38th to 48th amino acid residues. Accordingly, all three relatively invariant--therefore, conserved--framework regions (FW-1, FW-2, and FW-3) of VHs are specified by recognizable--therefore, conserved--descendants of the primordial sequence.
摘要
小鼠免疫球蛋白重链可变区（Ig VH）基因显然源自大约600个碱基对长的序列（约为48个碱基对长的原始构建模块序列TTC - AGC - AGC - CTG - ACT - GGA - TAT - GAC - CTG - GAG - TGG - ACT - TAC - TGC - GCA - AGA的12个串联重复），该序列在原始阅读框中编码氨基酸序列苯丙氨酸 - 丝氨酸 - 丝氨酸 - 亮氨酸 - 苏氨酸 - 甘氨酸 - 酪氨酸 - 天冬氨酸 - 亮氨酸 - 谷氨酸 - 色氨酸 - 苏氨酸 - 酪氨酸 - 半胱氨酸 - 丙氨酸 - 精氨酸。先前鉴定出的较短原型构建模块仅仅代表了上述原始序列的特定部分。即使在今天，这个原始序列的直系后代完整地指定了每个VH编码序列的最后六分之一：第83至98个氨基酸残基。此外，它的四个截短衍生物指定了第4至14、17至23、29至37以及38至48个氨基酸残基。因此，VH的所有三个相对不变（即保守）的构架区（FW - 1、FW - 2和FW - 3）由原始序列可识别（即保守）的后代指定。
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