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1
Identification of the 48-base-long primordial building block sequence of mouse immunoglobulin variable region genes.小鼠免疫球蛋白可变区基因48个碱基长的原始构建模块序列的鉴定。
Proc Natl Acad Sci U S A. 1982 Mar;79(6):1999-2002. doi: 10.1073/pnas.79.6.1999.
2
The 48-base-long primordial building block of immunoglobulin light-chain variable regions is complementary to the primordial building block of heavy-chain variable regions.免疫球蛋白轻链可变区48个碱基长的原始构建块与重链可变区的原始构建块互补。
Proc Natl Acad Sci U S A. 1982 Apr;79(7):2338-41. doi: 10.1073/pnas.79.7.2338.
3
Evolution is condemned to rely upon variations of the same theme: the one ancestral sequence for genes and spacers.进化注定要依赖于同一主题的变体：基因和间隔区的单一祖先序列。
Perspect Biol Med. 1982 Summer;25(4):559-72. doi: 10.1353/pbm.1982.0068.
4
Mouse immunoglobulin coding sequences for the heavy-chain variable region arose as repeats of the two short building blocks.小鼠重链可变区的免疫球蛋白编码序列是由两个短构建模块重复产生的。
Proc Natl Acad Sci U S A. 1982 Jan;79(1):132-6. doi: 10.1073/pnas.79.1.132.
5
Organization and evolution of immunoglobulin VH gene subgroups.免疫球蛋白VH基因亚群的组织与进化
Proc Natl Acad Sci U S A. 1982 Jul;79(14):4405-9. doi: 10.1073/pnas.79.14.4405.
6
Evolutionary aspects of immunoglobulin heavy chain variable region (VH) gene subgroups.免疫球蛋白重链可变区（VH）基因亚组的进化方面。
Proc Natl Acad Sci U S A. 1983 Feb;80(3):855-9. doi: 10.1073/pnas.80.3.855.
7
Structure and multiplicity of genes for the human immunoglobulin heavy chain variable region.人类免疫球蛋白重链可变区基因的结构与多样性
Proc Natl Acad Sci U S A. 1980 Nov;77(11):6561-5. doi: 10.1073/pnas.77.11.6561.
8
Recurrence of 49-base decamers, nonomers, and octamers within mouse C mu gene of Ig heavy chain and its primordial building block.小鼠免疫球蛋白重链Cμ基因及其原始构建模块内49个碱基的十聚体、九聚体和八聚体的重复情况。
Proc Natl Acad Sci U S A. 1983 Apr;80(8):2337-40. doi: 10.1073/pnas.80.8.2337.
9
Diversity of germ-line immunoglobulin VH genes.种系免疫球蛋白VH基因的多样性。
Nature. 1981 Jul 30;292(5822):426-30. doi: 10.1038/292426a0.
10
Original domain for the serum albumin family arose from repeated sequences.血清白蛋白家族的原始结构域源自重复序列。
Proc Natl Acad Sci U S A. 1981 Dec;78(12):7657-61. doi: 10.1073/pnas.78.12.7657.

引用本文的文献

1
Ancient phylogenetic beginnings of immunoglobulin hypermutation.免疫球蛋白超突变的古老系统发育起源。
J Mol Evol. 2006 Nov;63(5):691-706. doi: 10.1007/s00239-006-0051-9. Epub 2006 Oct 6.
2
Sequence similarities of protein kinase peptide substrates and inhibitors: comparison of their primary structures with immunoglobulin repeats.蛋白激酶肽底物与抑制剂的序列相似性：将它们的一级结构与免疫球蛋白重复序列进行比较。
Folia Microbiol (Praha). 2002;47(4):319-58. doi: 10.1007/BF02818689.
3
The genome of the THE I human transposable repetitive elements is composed of a basic motif homologous to an ancestral immunoglobulin gene sequence.THE I人类转座重复元件的基因组由与祖先免疫球蛋白基因序列同源的基本基序组成。
Proc Natl Acad Sci U S A. 1994 Aug 16;91(17):7967-9. doi: 10.1073/pnas.91.17.7967.
4
Identification of the 45-base-long primordial building block of the entire class I major histocompatibility complex antigen gene.鉴定整个I类主要组织相容性复合体抗原基因的45个碱基长的原始构建模块。
Proc Natl Acad Sci U S A. 1982 Oct;79(20):6342-6. doi: 10.1073/pnas.79.20.6342.
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The primitive code and repeats of base oligomers as the primordial protein-encoding sequence.作为原始蛋白质编码序列的原始密码和碱基寡聚物重复序列。
Proc Natl Acad Sci U S A. 1983 Jun;80(11):3391-5. doi: 10.1073/pnas.80.11.3391.
6
Recurrence of 49-base decamers, nonomers, and octamers within mouse C mu gene of Ig heavy chain and its primordial building block.小鼠免疫球蛋白重链Cμ基因及其原始构建模块内49个碱基的十聚体、九聚体和八聚体的重复情况。
Proc Natl Acad Sci U S A. 1983 Apr;80(8):2337-40. doi: 10.1073/pnas.80.8.2337.
7
Dissection of serological and cytolytic T lymphocyte epitopes on murine major histocompatibility antigens by a recombinant H-2 gene separating the first two external domains.通过分离前两个外部结构域的重组H-2基因剖析小鼠主要组织相容性抗原上的血清学和细胞溶解性T淋巴细胞表位
J Exp Med. 1984 Jul 1;160(1):167-78. doi: 10.1084/jem.160.1.167.
8
A new rule for analyzing homologous coding sequences in DNA.一种用于分析DNA中同源编码序列的新规则。
Nucleic Acids Res. 1984 Jan 11;12(1 Pt 1):159-73. doi: 10.1093/nar/12.1part1.159.
9
Immunoglobulin VH gene structure and diversity in Heterodontus, a phylogenetically primitive shark.在系统发育上原始的鲨鱼——宽纹虎鲨中免疫球蛋白VH基因的结构与多样性
Proc Natl Acad Sci U S A. 1985 Apr;82(7):2082-6. doi: 10.1073/pnas.82.7.2082.
10
Complete nucleotide sequences of three VH genes in Caiman, a phylogenetically ancient reptile: evolutionary diversification in coding segments and variation in the structure and organization of recombination elements.凯门鳄（一种系统发育上古老的爬行动物）中三个VH基因的完整核苷酸序列：编码区的进化多样性以及重组元件结构和组织的变异
Proc Natl Acad Sci U S A. 1985 Feb;82(3):844-8. doi: 10.1073/pnas.82.3.844.

本文引用的文献

1
Structure of C-terminal half of two H-2 antigens from cloned mRNA.来自克隆mRNA的两种H-2抗原C端半段的结构
Nature. 1981 Jul 2;292(5818):78-81. doi: 10.1038/292078a0.
2
Mouse immunoglobulin coding sequences for the heavy-chain variable region arose as repeats of the two short building blocks.小鼠重链可变区的免疫球蛋白编码序列是由两个短构建模块重复产生的。
Proc Natl Acad Sci U S A. 1982 Jan;79(1):132-6. doi: 10.1073/pnas.79.1.132.
3
A single VH gene segment encodes the immune response to phosphorylcholine: somatic mutation is correlated with the class of the antibody.单个VH基因片段编码对磷酸胆碱的免疫反应：体细胞突变与抗体类别相关。
Cell. 1981 Jul;25(1):59-66. doi: 10.1016/0092-8674(81)90231-2.
4
Diversity of germ-line immunoglobulin VH genes.种系免疫球蛋白VH基因的多样性。
Nature. 1981 Jul 30;292(5822):426-30. doi: 10.1038/292426a0.
5
Heavy chain variable region contribution to the NPb family of antibodies: somatic mutation evident in a gamma 2a variable region.重链可变区对NPb抗体家族的贡献：γ2a可变区中明显的体细胞突变。
Cell. 1981 Jun;24(3):625-37. doi: 10.1016/0092-8674(81)90089-1.
6
(AGCTG) (AGCTG) (AGCTG) (GGGTG) as the primordial sequence of intergenic spacers: the role in immunoglobulin class switch.（AGCTG）（AGCTG）（AGCTG）（GGGTG）作为基因间隔区的原始序列：在免疫球蛋白类别转换中的作用。
Differentiation. 1981;18(2):65-74. doi: 10.1111/j.1432-0436.1981.tb01106.x.
7
Two types of somatic recombination are necessary for the generation of complete immunoglobulin heavy-chain genes.产生完整的免疫球蛋白重链基因需要两种类型的体细胞重组。
Nature. 1980 Aug 14;286(5774):676-83. doi: 10.1038/286676a0.
8
Rearrangement of immunoglobulin gamma 1-chain gene and mechanism for heavy-chain class switch.免疫球蛋白γ1链基因重排及重链类别转换机制
Proc Natl Acad Sci U S A. 1980 Feb;77(2):919-23. doi: 10.1073/pnas.77.2.919.
9
Chi, a promoter of generalized recombination in lambda phage, is present in immunoglobulin genes.Chi是λ噬菌体中普遍重组的促进因子，存在于免疫球蛋白基因中。
Nature. 1981 Oct 1;293(5831):402-4. doi: 10.1038/293402a0.
10
Original domain for the serum albumin family arose from repeated sequences.血清白蛋白家族的原始结构域源自重复序列。
Proc Natl Acad Sci U S A. 1981 Dec;78(12):7657-61. doi: 10.1073/pnas.78.12.7657.

小鼠免疫球蛋白可变区基因48个碱基长的原始构建模块序列的鉴定。

Identification of the 48-base-long primordial building block sequence of mouse immunoglobulin variable region genes.

作者信息

Ohno S, Matsunaga T, Wallace R B

出版信息

Proc Natl Acad Sci U S A. 1982 Mar;79(6):1999-2002. doi: 10.1073/pnas.79.6.1999.

DOI:10.1073/pnas.79.6.1999
PMID:6804949
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC346109/
Abstract

Mouse immunoglobulin heavy-chain variable region (Ig VH) genes apparently arose from the approximately 600-base-pair-long (approximately 12 tandem repeats of the 48-base-pair-long primordial building block sequence TTC-AGC-AGC-CTG-ACT-GGA-TAT-GAC-CTG-GAG-TGG-ACT-TAC-TGC-GCA-AGA) that in the original reading frame specified the amino acid sequence Phe-Ser-Ser-Leu-Thr-Gly-Tyr-Asp-Leu-Glu-Trp-Thr-Tyr-Cys-Ala-Arg. The previously identified, shorter prototype building blocks merely represented particular portions of the above primordial sequence. Even today, the direct descendant in toto of this primordial sequence specifies the last one-sixth of each VH coding sequence: the 83rd to 98th amino acid residues. Furthermore, its four truncated derivatives specify the 4th to 14th, 17th to 23rd, 29th to 37th, and 38th to 48th amino acid residues. Accordingly, all three relatively invariant--therefore, conserved--framework regions (FW-1, FW-2, and FW-3) of VHs are specified by recognizable--therefore, conserved--descendants of the primordial sequence.

摘要

小鼠免疫球蛋白重链可变区（Ig VH）基因显然源自大约600个碱基对长的序列（约为48个碱基对长的原始构建模块序列TTC - AGC - AGC - CTG - ACT - GGA - TAT - GAC - CTG - GAG - TGG - ACT - TAC - TGC - GCA - AGA的12个串联重复），该序列在原始阅读框中编码氨基酸序列苯丙氨酸 - 丝氨酸 - 丝氨酸 - 亮氨酸 - 苏氨酸 - 甘氨酸 - 酪氨酸 - 天冬氨酸 - 亮氨酸 - 谷氨酸 - 色氨酸 - 苏氨酸 - 酪氨酸 - 半胱氨酸 - 丙氨酸 - 精氨酸。先前鉴定出的较短原型构建模块仅仅代表了上述原始序列的特定部分。即使在今天，这个原始序列的直系后代完整地指定了每个VH编码序列的最后六分之一：第83至98个氨基酸残基。此外，它的四个截短衍生物指定了第4至14、17至23、29至37以及38至48个氨基酸残基。因此，VH的所有三个相对不变（即保守）的构架区（FW - 1、FW - 2和FW - 3）由原始序列可识别（即保守）的后代指定。