Miczek K A
Prog Neuropsychopharmacol Biol Psychiatry. 1983;7(4-6):519-24. doi: 10.1016/0278-5846(83)90019-2.
Psychopharmacological research on aggression pursues divergent objectives: From a pharmacological perspectives, animal aggression tests are employed in order to differentiate classes of psychotherapeutic drugs and to screen for specific agents. Psychiatric interests in animal aggression research attempt to model pathological aggressive behavior in humans. These efforts have yielded disappointing results because they are based neither on a detailed understanding of the behavioral characteristics of aggression nor of the relevant neural processes. The ethological approach to aggression research focuses on biologically relevant situations and behavior patterns. Quantitative methods describe drug action on the interactive and episodic nature of aggressive behavior. An analysis of the temporal pattern of aggressive behavior indicates how, for example, amphetamine and alcohol modulate sequences of aggressive interactions.
从药理学角度来看，动物攻击行为测试被用于区分精神治疗药物的类别并筛选特定药物。精神病学对动物攻击行为研究的兴趣在于试图模拟人类的病理性攻击行为。这些努力产生了令人失望的结果，因为它们既没有基于对攻击行为的行为特征的详细理解，也没有基于对相关神经过程的详细理解。攻击行为研究的行为学方法侧重于生物学上相关的情境和行为模式。定量方法描述了药物对攻击行为的交互性和偶发性的作用。对攻击行为的时间模式的分析表明，例如，安非他命和酒精是如何调节攻击互动序列的。
