肾上腺素、促甲状腺激素（TSH）释放激素、多巴胺和生长抑素在体外对促甲状腺激素分泌的调控中的相互作用。
Interactions among epinephrine, thyrotropin (TSH)-releasing hormone, dopamine, and somatostatin in the control of TSH secretion in vitro.
作者信息
Dieguez C, Foord S M, Peters J R, Hall R, Scanlon M F
出版信息
Endocrinology. 1984 Mar;114(3):957-61. doi: 10.1210/endo-114-3-957.
Epinephrine and TRH independently release TSH from rat anterior pituitary cells in primary monolayer culture (ED50, 11 and 5 nM, respectively; maximum responses, 80% and 110%, respectively). The effects of these compounds together are additive, even at concentrations at which each is maximally effective alone. Dopamine inhibited basal and epinephrine-stimulated TSH secretion by 25 +/- 5% (+/-SE; ED50, 50 +/- 9 nM in each case). Somatostatin was effective against epinephrine-stimulated, but not basal, TSH secretion (80 +/- 4% inhibition; ED50, 1 +/- 3 nM). The data show that epinephrine is a potential regulator of TSH secretion by its own action and via its interactions with TRH, dopamine, and somatostatin.
肾上腺素和促甲状腺激素释放激素（TRH）可分别从原代单层培养的大鼠垂体前叶细胞中释放促甲状腺激素（TSH）（半数有效浓度[ED50]分别为11 nM和5 nM；最大反应分别为80%和110%）。即使在每种化合物单独作用时已达到最大效应的浓度下，这两种化合物共同作用的效果仍是相加的。多巴胺可抑制基础状态下以及肾上腺素刺激后的TSH分泌，抑制率为25±5%（±标准误[SE]；每种情况下的ED50为50±9 nM）。生长抑素可有效抑制肾上腺素刺激后的TSH分泌，但对基础状态下的TSH分泌无效（抑制率为80±4%；ED50为1±3 nM）。这些数据表明，肾上腺素可通过自身作用以及与TRH、多巴胺和生长抑素的相互作用，成为TSH分泌的潜在调节因子。
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