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腺苷激动剂可抑制大鼠齿状回切片中谷氨酸的释放，但不影响γ-氨基丁酸（GABA）的释放；而环磷酸腺苷类似物则可增强谷氨酸的释放，同样不影响GABA的释放。

An adenosine agonist inhibits and a cyclic AMP analogue enhances the release of glutamate but not GABA from slices of rat dentate gyrus.

作者信息

Dolphin A C, Archer E R

出版信息

Neurosci Lett. 1983 Dec 23;43(1):49-54. doi: 10.1016/0304-3940(83)90127-1.

DOI:10.1016/0304-3940(83)90127-1
PMID:6142434
Abstract

The adenosine agonist 2-chloroadenosine inhibited the K+-induced release of endogenously synthesized [3H]glutamate but not [3H]GABA from slices of rat dentate gyrus. In contrast, the K+-stimulated release of [3H]glutamate was augmented by the adenosine antagonist theophylline and was further enhanced by the cyclic AMP analogue 8-bromo-cyclic AMP in the presence of theophylline.

摘要

腺苷激动剂2-氯腺苷抑制了钾离子诱导的大鼠齿状回切片中内源性合成的[3H]谷氨酸的释放，但不影响[3H]γ-氨基丁酸的释放。相反，腺苷拮抗剂茶碱增强了钾离子刺激的[3H]谷氨酸的释放，并且在茶碱存在的情况下，环磷酸腺苷类似物8-溴环磷酸腺苷进一步增强了这种释放。

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