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[三支血管狭窄性冠状动脉粥样硬化患者的生存情况]

[Survival of patients with triple-vessel stenosing coronary atheroma].

作者信息

Metzger J P, Wertheimer J, Fermanian J, Ployart F, Baubion N, Bloch E, de Metz S, Vacheron A

出版信息

Arch Mal Coeur Vaiss. 1984 Feb;77(2):174-9.

PMID:6143544
Abstract

This study analysed the survival rate of 179 patients with triple vessel coronary artery disease, 168 men and 11 women (mean age 54 years). Seventeen cases of left main stem disease were excluded. The patients presented with unstable angina (64 cases), stable angina (66 cases), recent myocardial infarction (26 cases) or chronic invalidating angina (23 cases). Coronary bypass surgery was undertaken whenever possible (64 cases, 34% of patients). Medical therapy (115 cases) was based on betablockers (61%), amiodarone (22%) and perhexiline (17%). The study was carried out by a double questionnaire sent to the patient and treating physician, 6 months to 76 months after coronary angiography (average 30 months). The response to these questionnaires was 100%. Survival rates were calculated by actuarial methods. Comparisons of survival graphs was made using the Log Rang test. The overall survival rate was 89% at 1 year, 84% at 2 years, 82% at 5 years and 71% at 6 years. There seemed to be a lower mortality in the surgical group (p less than 0,28). The 2 year survival rate in the group with cardiac failure was 40% compared with 88% in the group without cardiac failure (p less than 0,001). There was no statistically significant difference in mortality except in patients with ejection fractions lower than 0,30. Analysis of survival with respect to mode of presentation did not show any significant difference between patients with unstable angina, stable angina or chronic invalidating angina. Mortality was higher when triple vessel disease was discovered during myocardial infarction, reaching 33% at 4 years, compared to 15% in the other subgroups (p less than 0,05).(ABSTRACT TRUNCATED AT 250 WORDS)

摘要

本研究分析了179例三支血管冠状动脉疾病患者的生存率,其中男性168例,女性11例(平均年龄54岁)。排除17例左主干疾病患者。患者表现为不稳定型心绞痛(64例)、稳定型心绞痛(66例)、近期心肌梗死(26例)或慢性致残性心绞痛(23例)。尽可能进行冠状动脉搭桥手术(64例,占患者的34%)。药物治疗(115例)基于β受体阻滞剂(61%)、胺碘酮(22%)和哌克昔林(17%)。该研究通过在冠状动脉造影后6个月至76个月(平均30个月)向患者和治疗医师发送双重问卷进行。对这些问卷的回复率为100%。生存率采用精算方法计算。使用对数秩检验对生存曲线进行比较。1年时总生存率为89%,2年时为84%,5年时为82%,6年时为71%。手术组的死亡率似乎较低(p<0.28)。心力衰竭组的2年生存率为40%,而无心力衰竭组为88%(p<0.001)。除射血分数低于0.30的患者外,死亡率无统计学显著差异。就表现方式分析生存率,不稳定型心绞痛、稳定型心绞痛或慢性致残性心绞痛患者之间未显示出任何显著差异。在心肌梗死期间发现三支血管疾病时死亡率较高,4年时达到33%,而其他亚组为15%(p<0.05)。(摘要截短至250字)

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