Dubois C, Brodaty D, Lacour-Gayet F, Genet L, Bachet J, Goudot B, Tawil N, Richard T, Teboul B, Guilmet D
Arch Mal Coeur Vaiss. 1983 Sep;76(9):1004-11.
Between 1970 and 1972, 183 patients were admitted to the CMC Foch (Pr D. Guilmet) for saphenous vein aorto-coronary bypass surgery. Ten years later a questionnaire was sent to the patient and his cardiologist and the two replies were analysed. Before surgery, all patients had invalidating angina: 12 p. 100 had unstable angina, 61 p. 100 had previous myocardial infarction. Preoperative coronary angiography showed triple vessel disease in 64,5 p. 100, double vessel disease in 18,6 p. 100 and single vessel disease in 14,2 p. 100. There hundred and thirty two grafts were performed (average 1,8 per patient); 42 endarteriectomies were also carried out, 35 on the right coronary artery. Complete revascularisation was achieved in 95 cases (52 p. 100). The incidence of perioperative infarction was 17,5 p. 100 and operative mortality was 7,6 p. 100. Thirty two patients (19 p. 100) died during the 10 year study period; 11 deaths were of cardiovascular origin. The 10 year actuarial survival rate was 66 p. 100. Half the patients are asymptomatic and nearly two thirds take no anti-anginal therapy. The patency of the grafts was chacked in about half the cases and was found to be 72,8 p. 100 at one year. From the professional point of view, two thirds of patients returned to full time working one year after surgery. The degree of activity at 10 years is only known in 87 cases; half these patients are working and a quarter have retired normally. This study shows that: --coronary bypass surgery has excellent long-term effects on symptoms; --the incidence of infarction and survival are comparable to other reported studies; --patients with triple or double vessel disease may have lived longer after surgery than had they been treated medically.
1970年至1972年间,183例患者因隐静脉主动脉 - 冠状动脉搭桥手术入住福煦中心医院(由D. 吉尔梅医生负责)。10年后,向患者及其心脏病专家发送了一份问卷,并对两份回复进行了分析。手术前,所有患者均患有致残性心绞痛:12%患有不稳定型心绞痛,61%曾有过心肌梗死。术前冠状动脉造影显示,64.5%的患者为三支血管病变,18.6%为双支血管病变,14.2%为单支血管病变。共进行了132次移植手术(平均每位患者1.8次);还进行了42次动脉内膜切除术,其中35次针对右冠状动脉。95例患者(52%)实现了完全血运重建。围手术期梗死发生率为17.5%,手术死亡率为7.6%。在为期10年的研究期间,32例患者(19%)死亡;11例死于心血管疾病。10年精算生存率为66%。一半的患者无症状,近三分之二的患者无需服用抗心绞痛药物。约一半的病例检查了移植血管的通畅情况,发现术后一年通畅率为72.8%。从职业角度来看,三分之二的患者术后一年恢复全职工作。仅87例患者得知了他们术后10年的活动程度;其中一半患者仍在工作,四分之一已正常退休。这项研究表明:——冠状动脉搭桥手术对症状具有极佳的长期疗效;——梗死发生率和生存率与其他报道的研究相当;——患有三支或双支血管病变的患者手术后可能比接受药物治疗活得更长。