Ereshefsky L, Saklad S R, Jann M W, Davis C M, Richards A, Seidel D R
J Clin Psychiatry. 1984 May;45(5 Pt 2):50-9.
The future of depot neuroleptic therapy is discussed in terms of pharmacokinetic and pharmacodynamic research opportunities. Analytic methods for neuroleptic assays, including chromatographic, radioreceptor, nuclear magnetic resonance, and radioimmunoassay techniques, are briefly reviewed. Elucidation of depot neuroleptic multicompartment kinetics utilizing nonlinear mixed-effects modeling and the usefulness of these data in interpreting plasma levels are discussed. The clinical significance of plasma monitoring of depot fluphenazine, including the development of dosage conversion guidelines, is presented. The relationships between haloperidol and its metabolite reduced haloperidol (RH) are discussed in terms of dosage form and response. Clinical advantages resulting from the availability of more depot neuroleptics are discussed.
本文从药代动力学和药效学的研究机会方面探讨了长效抗精神病药物治疗的未来。简要回顾了抗精神病药物分析方法，包括色谱法、放射受体法、核磁共振法和放射免疫分析法。讨论了利用非线性混合效应模型阐明长效抗精神病药物的多室动力学及其在解释血浆水平方面的作用。介绍了长效氟奋乃静血浆监测的临床意义，包括剂量转换指南的制定。从剂型和反应方面讨论了氟哌啶醇与其代谢产物还原氟哌啶醇（RH）之间的关系。讨论了更多长效抗精神病药物的可获得性所带来的临床优势。
