Vichyanond P, Olson L C
Arch Neurol. 1984 Jun;41(6):637-9. doi: 10.1001/archneur.1984.04210080045011.
Three children had staphylococcal infections of the CNS. In two cases the organisms were resistant to methicillin sodium. Each case was treated with a combination of vancomycin hydrochloride and rifampin; in one instance vancomycin alone had been unsuccessful. The addition of rifampin resulted in prompt clinical and bacteriologic resolution. Satisfactory levels of rifampin were achieved by administering the drug either orally or intravenously, and in one patient oral administration of rifampin produced assayed levels in subdural pus many times that required for minimal bactericidal activity. Combination therapy with vancomycin and rifampin is recommended for staphylococcal infections of the CNS.
三名儿童患有中枢神经系统葡萄球菌感染。其中两例感染的病菌对甲氧西林钠耐药。每例均采用盐酸万古霉素和利福平联合治疗；有一例单独使用万古霉素治疗未成功。加用利福平后临床症状迅速缓解且细菌学检查结果转阴。通过口服或静脉给药均可使利福平达到满意的血药浓度，在一名患者中，口服利福平后硬膜下脓液中的检测浓度是最低杀菌活性所需浓度的许多倍。对于中枢神经系统葡萄球菌感染，建议采用万古霉素和利福平联合治疗。
