Fujimoto Y, Tanioka H, Toibana E, Yamamoto T, Fujita T
J Pharm Pharmacol. 1984 Mar;36(3):195-7. doi: 10.1111/j.2042-7158.1984.tb06939.x.
The inhibitory effects of NN'-diphenyl-p-phenylenediamine (DPPD), sodium diethyldithiocarbamate (SDDC) and 2,6-di-t-butylphenol (DTBP) on the generation of medullary prostaglandin E have been compared. DPPD (1 microM) and SDDC (1 mM) failed to inhibit arachidonic acid-induced stimulation of prostaglandin E synthesis, while DTBP (1 mM) inhibited it. This suggests that DPPD and SDDC inhibit prostaglandin formation by affecting a phospholipase pathway, and the inhibition of prostaglandin generation by DTBP occurs at the cyclooxygenase step.
已比较了N，N'-二苯基对苯二胺（DPPD）、二乙基二硫代氨基甲酸钠（SDDC）和2,6-二叔丁基苯酚（DTBP）对髓质前列腺素E生成的抑制作用。DPPD（1微摩尔）和SDDC（1毫摩尔）未能抑制花生四烯酸诱导的前列腺素E合成刺激，而DTBP（1毫摩尔）则能抑制。这表明DPPD和SDDC通过影响磷脂酶途径抑制前列腺素形成，而DTBP对前列腺素生成的抑制发生在环氧化酶步骤。
