对具有镰状细胞性状和正常血红蛋白的牙买加成年人进行了十二年随访后的死亡率和发病率。

Mortality and morbidity in Jamaican adults with sickle-cell trait and with normal haemoglobin followed up for twelve years.

作者信息

Ashcroft M T, Desai P

出版信息

Lancet. 1976 Oct 9;2(7989):784-6. doi: 10.1016/s0140-6736(76)90612-7.

Abstract

An epidemiological survey of adults aged 35--64 years living in a rural area of Jamaica was started in 1962--63 and continued until 1975. Information was available on 856 subjects with AA and 119 subjects with AS haemoglobin genotypes. The mortality-rates over 12 or 13 years and the number of clinic attendances in 10 years did not differ significantly between subjects with AA and those with AS haemoglobin. The patterns of disease as well as the life expectancy of the two groups appeared to be the same.

摘要

1962年至1963年，对居住在牙买加农村地区的35至64岁成年人展开了一项流行病学调查，并持续至1975年。研究获取了856名携带AA血红蛋白基因型个体以及119名携带AS血红蛋白基因型个体的信息。携带AA血红蛋白的个体与携带AS血红蛋白的个体在12年或13年期间的死亡率以及10年内的门诊就诊次数并无显著差异。两组的疾病模式以及预期寿命似乎相同。