Schade R R, Van Thiel D H, Gavaler J S
Dig Dis Sci. 1984 Jul;29(7):614-9. doi: 10.1007/BF01347293.
Many frequently cited studies of the interaction of chronic idiopathic ulcerative colitis (CIUC) and pregnancy were performed in the 1950s before pharmacotherapy for this disease was common. We retrospectively reviewed obstetrical records at a large maternity facility to determine the effects of CIUC on pregnancy and on fetal outcome. We observed that the prevalence of CIUC in pregnant women was below that expected based on published data (P less than 0.01). The use of prednisone and sulfasalazine in pregnant women with CIUC was common; 85% of these patients received these medications. We found significantly greater (P less than 0.01) incidence of low-birth-weight in infants (less than 2500 g) of mothers with CIUC than in the control population. The delivery of infants of low birth weight occurred despite adequate maternal weight gain.
许多关于慢性特发性溃疡性结肠炎（CIUC）与妊娠相互作用的经常被引用的研究是在20世纪50年代进行的，那时针对这种疾病的药物治疗还不普遍。我们回顾性地查阅了一家大型产科机构的产科记录，以确定CIUC对妊娠和胎儿结局的影响。我们观察到，孕妇中CIUC的患病率低于根据已发表数据预期的患病率（P<0.01）。患有CIUC的孕妇使用泼尼松和柳氮磺胺吡啶很常见；这些患者中有85%接受了这些药物治疗。我们发现，患有CIUC的母亲所生婴儿（体重低于2500克）的低出生体重发生率显著高于（P<0.01）对照组。尽管母亲体重增加充足，但仍出现了低出生体重婴儿的分娩情况。
