Morris D L, Youngs D, Muscroft T J, Cooper J, Rojinski C, Burdon D W, Keighley M R
Gut. 1984 Jul;25(7):723-7. doi: 10.1136/gut.25.7.723.
Mutagenicity has been measured in the gastric juice of 228 patients using the Ames bacteriological test system; while mutagenicity in control and duodenal ulcer patients did not differ from saline controls, mutagenicity was significantly increased compared with controls in patients suffering gastric ulcer (p less than 0.002), carcinoma (p less than 0.002), and in patients after gastric resection (p less than 0.01). A transient rise in mutagenicity was seen following H2 antagonist ingestion (p less than 0.002). Increased levels of mutagenicity were found to correlate closely with gastric juice pH and bacterial count. Histidine concentrations in gastric juice did not explain the mutagenicity results.
使用艾姆斯细菌检测系统对228例患者的胃液进行了致突变性检测；对照患者和十二指肠溃疡患者的致突变性与生理盐水对照组无差异，但胃溃疡患者（p<0.002）、癌症患者（p<0.002）以及胃切除术后患者（p<0.01）的致突变性与对照组相比显著增加。摄入H2拮抗剂后致突变性出现短暂升高（p<0.002）。发现致突变性水平升高与胃液pH值和细菌计数密切相关。胃液中的组氨酸浓度无法解释致突变性结果。
