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病毒感染后疲惫/疲劳综合征患者运动时骨骼肌细胞内酸中毒过度。一项31P核磁共振研究。

Excessive intracellular acidosis of skeletal muscle on exercise in a patient with a post-viral exhaustion/fatigue syndrome. A 31P nuclear magnetic resonance study.

作者信息

Arnold D L, Bore P J, Radda G K, Styles P, Taylor D J

出版信息

Lancet. 1984 Jun 23;1(8391):1367-9. doi: 10.1016/s0140-6736(84)91871-3.

DOI:10.1016/s0140-6736(84)91871-3
PMID:6145831
Abstract

A patient with prolonged post-viral exhaustion and excessive fatigue was examined by 31P nuclear magnetic resonance. During exercise, muscles of the forearm demonstrated abnormally early intracellular acidosis for the exercise performed. This was out of proportion to the associated changes in high-energy phosphates. This may represent excessive lactic acid formation resulting from a disorder of metabolic regulation. The metabolic abnormality in this patient could not have been demonstrated by traditional diagnostic techniques.

摘要

一名患有病毒感染后长期疲惫和过度疲劳的患者接受了31P核磁共振检查。在运动过程中,前臂肌肉在进行的运动中表现出异常早期的细胞内酸中毒。这与高能磷酸盐的相关变化不成比例。这可能代表代谢调节紊乱导致的乳酸过度生成。传统诊断技术无法证实该患者的代谢异常。

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