Slama G, Haardt M J, Jean-Joseph P, Costagliola D, Goicolea I, Bornet F, Elgrably F, Tchobroutsky G
Lancet. 1984 Jul 21;2(8395):122-5. doi: 10.1016/s0140-6736(84)91045-6.
The hyperglycaemic effect of 20 g sucrose taken at the end of a regular mixed meal by diabetic patients was measured in six adult type 1 diabetics, C-peptide negative, controlled by the artificial pancreas, and twelve adult type 2 diabetics, with fasting plasma glucose levels below 7.2 mmol/l (130 mg/100 ml) and post-prandial plasma glucose levels below 10.0 mmol/l (180 mg/100 ml), treated by diet alone or with glibenclamide and/or metformin. All the patients were given on consecutive days, in random order, two mixed meals of grilled meat, green beans, and cheese, as well as a cake made either of rice, skimmed milk, and saccharine (meal A) or rice, skimmed milk, and 20 g sucrose (meal B). The meals contained equal amounts of calories and of carbohydrate. There was no difference between the meals in plasma glucose curves and plasma insulin or insulin infusion rate variations whether in peak values, peaking times, or areas under the curves, in either group of patients. Sparing use of sucrose taken during mixed meals might help well-controlled diabetic patients to comply with their daily dietary prescription while maintaining good blood glucose control.
对6名由人工胰腺控制的成年1型糖尿病患者（C肽阴性）以及12名成年2型糖尿病患者进行了测量，这些2型糖尿病患者空腹血糖水平低于7.2 mmol/L（130 mg/100 ml），餐后血糖水平低于10.0 mmol/L（180 mg/100 ml），通过单纯饮食或联合格列本脲和/或二甲双胍进行治疗。所有患者连续数天以随机顺序食用两份混合餐（烤牛肉、青豆和奶酪），以及一份由大米、脱脂牛奶和糖精制成的蛋糕（餐A）或由大米、脱脂牛奶和20 g蔗糖制成的蛋糕（餐B）。这些餐食含有等量的热量和碳水化合物。无论是在峰值、达峰时间还是曲线下面积方面，两组患者的血浆葡萄糖曲线、血浆胰岛素或胰岛素输注率变化在餐食之间均无差异。在混合餐期间适量使用蔗糖可能有助于血糖控制良好的糖尿病患者遵守日常饮食规定，同时维持良好的血糖控制。
