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醛类和醇类对多甲藻(Gonyaulax polyedra)蛋白质合成的影响:与昼夜节律振荡中的相移效力的关系。

Effects of aldehydes and alcohols on protein synthesis in the dinoflagellate, Gonyaulax polyedra: relation to phase-shifting potency in the circadian oscillation.

作者信息

Volknandt W, Hardeland R

出版信息

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1984;78(1):51-4. doi: 10.1016/0742-8413(84)90047-1.

DOI:10.1016/0742-8413(84)90047-1
PMID:6146484
Abstract

In Gonyaulax polyedra, protein synthesis was measured in vivo and in an in vitro translating system. Aldehydes applied in concentrations by which the circadian oscillator is phase-shifted inhibited protein synthesis considerably, both in vivo and in vitro. The efficiency of the drugs decreased with increasing chain length. Alcohols, though given in much higher concentrations, showed only weak effects. Therefore, the phase-shifting potency of aldehydes can be explained by a general mechanism influencing the circadian oscillator, namely through inhibition of protein synthesis, whereas this is obviously not the case in alcohols.

摘要

在多甲藻(Gonyaulax polyedra)中,在体内和体外翻译系统中测量了蛋白质合成。以能使昼夜节律振荡器发生相移的浓度施用的醛类物质,在体内和体外均显著抑制蛋白质合成。药物的效力随着链长的增加而降低。醇类物质虽然施用浓度要高得多,但只显示出微弱的作用。因此,醛类物质的相移效力可以通过一种影响昼夜节律振荡器的一般机制来解释,即通过抑制蛋白质合成,而醇类物质显然并非如此。

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