Matthias D, Engler E, Will-Shahab L, Herrmann H J, Becker C H
Acta Biol Med Ger. 1977;36(9):1279-84.
A 14-days' training of rats designed to adapt the animals to the procedure of blood-pressure measurement caused in the myocardium a decrease, in serum an increase in noradrenaline ( NA) content. The latter remained unchanged following 3 days of treatment with 2.5 mg depot angiotensin II (AII) but decreased by more than one-half in the myocardium of untreated animals, and increased in serum. Despite the considerable difference in myocardial NA content and blood-pressure behaviour, both trained and untrained rats showed the same morphological reactions following administration of A II. These myocardial alterations which largely correspond to the so-called epinephrine myocarditis should not therefore be due solely to NA action; rather, the involvement of A II should be considered also.
对大鼠进行为期14天的训练，以使动物适应血压测量过程，这导致心肌中去甲肾上腺素（NA）含量减少，血清中NA含量增加。用2.5mg长效血管紧张素II（AII）治疗3天后，血清中NA含量保持不变，但未治疗动物的心肌中NA含量减少了一半以上，而血清中NA含量增加。尽管心肌NA含量和血压表现存在相当大的差异，但训练和未训练的大鼠在给予AII后均表现出相同的形态学反应。因此，这些在很大程度上与所谓的肾上腺素性心肌炎相对应的心肌改变不应仅仅归因于NA的作用；相反，也应考虑AII的参与。
