Beaton J H, Gibson F, Roland M
Int J Fertil. 1984;29(2):109-12.
Fifty-six women with minor vaginal irritation, some associated with infertility, and with negative wet mount examination for common vaginal pathogens, used a disposable povidone-iodine-containing preparation (Betadine Medicated Douche) in a one-week trial. Of the 185 patient complaints, which included discharge, odor, pruritus, erythema, burning, and discomfort, 94 percent cleared completely and 4 percent were partially relieved. Odor cleared completely in 97 percent of affected cases and pruritus, discharge and chafing in 96, 91, and 100 percent, respectively. In all, 98 percent of the patients responded favorably. Those who became asymptomatic included women with past histories of repeated vaginal infections or on oral contraceptives, as well as a diabetic and patients with intrauterine devices. The douche caused no adverse effects and was well accepted by the patients. The present results favor short-term trial of the povidone-iodine douche in minor vaginal irritation of unknown etiology, before full laboratory investigation is undertaken.
56名有轻微阴道刺激症状（部分伴有不孕）且阴道分泌物涂片检查未发现常见阴道病原体的女性，参与了一项为期一周的试用，使用了一种含聚维酮碘的一次性制剂（碘伏药用灌洗器）。在185例患者的主诉中，包括分泌物异常、异味、瘙痒、红斑、灼痛和不适，94%的症状完全消除，4%的症状得到部分缓解。97%的有异味病例异味完全消除，瘙痒、分泌物异常和摩擦症状完全消除的比例分别为96%、91%和100%。总体而言，98%的患者反应良好。无症状的患者包括有反复阴道感染病史或正在服用口服避孕药的女性，以及一名糖尿病患者和使用宫内节育器的患者。该灌洗器未引起不良反应，且患者接受度良好。目前的结果表明，在进行全面实验室检查之前，对于病因不明的轻微阴道刺激症状，可对聚维酮碘灌洗器进行短期试用。
