Morris G P, Harding R K, Wallace J L
Virchows Arch B Cell Pathol Incl Mol Pathol. 1984;46(3):239-51. doi: 10.1007/BF02890313.
There is no morphologically detectable, continuous layer of extracellular mucus over the undamaged gastric mucosa of the rat. Instead, the mucosa is only partially covered by an interconnected network of mucous strands and sheets. This mucus is strongly acidic (sulphated) and is released by epithelial cells which line the isthmic and lower foveolar regions of the gastric glands of the fundus. A thick layer of gelatinous mucus is, however, released within 5 min after topical application of ulcerogenic agents. This mucus is released as a result of exfoliation and disintegration of interfoveolar surface epithelial cells. The released mucous glycoprotein is neutral or weakly acidic and is readily distinguished from the fibrous mucus produced by the epithelial cells which line the upper regions of the gastric glands. The preexisting network of acidic, fibrous mucus is retained at the luminal surface of the mucous cap which is produced over sites of damage. The layer of fibrous mucus is reinforced during the development of mucosal damage by accelerated release of mucous strands from the gastric glands. We propose that the fibrous mucus acts as an external, restraining layer to maintain the locally released, gelatinous mucus over sites of damage during a period in which epithelial continuity is restored by emigration of cells from the gastric glands.
在大鼠未受损的胃黏膜上，没有形态学上可检测到的连续细胞外黏液层。相反，黏膜仅部分被黏液丝和黏液片相互连接的网络覆盖。这种黏液呈强酸性（硫酸化），由位于胃底部胃腺峡部和小凹下部区域的上皮细胞释放。然而，在局部应用致溃疡剂后5分钟内会释放出一层厚厚的凝胶状黏液。这种黏液是由于小凹间表面上皮细胞的脱落和崩解而释放的。释放的黏液糖蛋白呈中性或弱酸性，很容易与胃腺上部区域上皮细胞产生的纤维状黏液区分开来。预先存在的酸性纤维状黏液网络保留在损伤部位产生的黏液帽的腔表面。在黏膜损伤发展过程中，通过胃腺加速释放黏液丝，纤维状黏液层得到加强。我们认为，在细胞从胃腺迁移恢复上皮连续性的一段时间内，纤维状黏液作为外部限制层，在损伤部位维持局部释放的凝胶状黏液。
