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感染Friend白血病病毒的致死剂量照射小鼠对造血细胞的天然抵抗力。

Natural resistance against hematopoietic cells in lethally-irradiated mice infected with Friend leukemia virus.

作者信息

Iorio A M, Neri M, Enrico P, Titti F, Rossi G B, Bonmassar E

出版信息

Cancer Immunol Immunother. 1984;18(1):35-40. doi: 10.1007/BF00205397.

Abstract

The influence of in vivo infection with the polycythemic substrain of Friend leukemia virus on noninducible ('natural') resistance against allogeneic normal or malignant grafts was studied in lethally irradiated mice. Parallel studies were performed on the NK system in the same experimental conditions. The results indicate that FLV-P infection of mice with full (DBA/2) vs partial (BALB/c and CD2F1) susceptibility did not suppress their in vivo natural resistance against bone marrow or El-4 leukemia cells. On the other hand, a decline in NK activity paralleled the progression of leukemic disease in the more susceptible DBA/2 hosts.

摘要

在接受致死剂量照射的小鼠中,研究了感染弗瑞德白血病病毒红细胞增多亚株对同种异体正常或恶性移植物的非诱导性(“天然”)抗性的影响。在相同实验条件下,对自然杀伤(NK)系统进行了平行研究。结果表明,完全易感(DBA/2)与部分易感(BALB/c和CD2F1)的小鼠感染FLV-P后,并未抑制它们对骨髓或El-4白血病细胞的体内天然抗性。另一方面,在更易感的DBA/2宿主中,NK活性的下降与白血病的进展平行。

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Do NK cells play a role in anti-tumor surveillance?自然杀伤细胞在抗肿瘤监测中发挥作用吗?
Immunol Today. 1980 Nov;1(5):96-100. doi: 10.1016/0167-5699(80)90041-9. Epub 2004 Aug 25.

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