Migliorati G, Jezzi T, Frati L, Bonmassar E, Rossi G B, Garaci E, Riccardi C
Int J Cancer. 1983 Jan 15;31(1):81-90. doi: 10.1002/ijc.2910310114.
We analyzed the effects of a polycythemic substrain of Friend leukemia virus, i.e. the FLV-P virus, on splenic NK activity of DBA/2 susceptible mice. One day after virus injection a significant increase of NK activity was found, which persisted until day 10. On the other hand, 14-21 days after virus injection a marked and significant depression of activity was measured. This depression was associated with the appearance of suppressor cells able to inhibit the lytic activity of untreated splenocytes when mixed in vitro in the 4 h 51Cr-release assay. The suppressor cell population was insensitive to treatment with anti-Thy 1.2 plus complement, was adherent to Sephadex G-10 and nylon, but did not adhere to plastic, suggesting it is neither a T-cell nor a typical macrophage. The possible relevance of NK activity modulation in relation to the induction of leukemia is discussed.
我们分析了弗氏白血病病毒的一个红细胞增多亚株，即FLV-P病毒，对DBA/2易感小鼠脾脏自然杀伤（NK）活性的影响。病毒注射一天后，发现NK活性显著增加，这种增加一直持续到第10天。另一方面，病毒注射14 - 21天后，检测到活性明显且显著降低。这种降低与抑制细胞的出现有关，在4小时51Cr释放试验中，当这些抑制细胞与未处理的脾细胞在体外混合时，能够抑制其裂解活性。抑制细胞群体对抗Thy 1.2加补体处理不敏感，能黏附于葡聚糖凝胶G - 10和尼龙，但不黏附于塑料，这表明它既不是T细胞也不是典型的巨噬细胞。本文讨论了NK活性调节与白血病诱导之间可能的相关性。
