大鼠离散脑核中γ-氨基丁酸和谷氨酸浓度的性别差异。

Sex differences in gamma-aminobutyric acid and glutamate concentrations in discrete rat brain nuclei.

作者信息

Frankfurt M, Fuchs E, Wuttke W

出版信息

Neurosci Lett. 1984 Sep 7;50(1-3):245-50. doi: 10.1016/0304-3940(84)90493-2.

Abstract

gamma-Aminobutyric acid (GABA) and glutamate concentrations were measured in discrete brain nuclei in adult male and female rats. Significant sex differences in GABA and glutamate concentrations were found in the medical preoptic area (MPA) and ventromedial hypothalamic area (VMH) as well as the lateral hypothalamus, habenula and diagonal band for glutamate. Significant differences in GABA and glutamate concentrations were also observed throughout the estrous cycle in several brain areas. These results suggest that these neuronal systems are sexually differentiated as well as involved in the expression of gonadal steroid feedback.

摘要

在成年雄性和雌性大鼠的离散脑核中测量了γ-氨基丁酸（GABA）和谷氨酸的浓度。在视前内侧区（MPA）、腹内侧下丘脑区（VMH）以及谷氨酸的外侧下丘脑、缰核和斜角带中发现了GABA和谷氨酸浓度的显著性别差异。在几个脑区的整个发情周期中也观察到了GABA和谷氨酸浓度的显著差异。这些结果表明，这些神经元系统存在性别分化，并且参与性腺类固醇反馈的表达。