[公牛大脑皮质中特异性苯二氮䓬结合的内源性抑制剂]
[Endogenous inhibitors of specific benzodiazepine binding in the cerebral cortex of the bull].
作者信息
Kladnitskiĭ A V, Mukhin A G
出版信息
Biull Eksp Biol Med. 1984 Oct;98(10):439-41.
PMID:6149775
Abstract
Chromatography of an acidic extract from bovine brain cortex on a Sephadex G-10 column demonstrated 7 fractions capable of inhibiting specific binding of 3H-diazepam to brain cortex membranes. It was established by ultrafiltration that the molecular weights of the inhibitors were not higher than 5000 dalton. Scatchard analysis of 4 main fractions has revealed a type of inhibition similar to the competitive one. Activity of all the fractions remained unchanged after pronase treatment.
摘要
用葡聚糖凝胶G - 10柱对牛脑皮质的酸性提取物进行色谱分析，结果显示有7个组分能够抑制³H - 地西泮与脑皮质膜的特异性结合。通过超滤确定，这些抑制剂的分子量不高于5000道尔顿。对4个主要组分进行的Scatchard分析显示，其抑制类型类似于竞争性抑制。经链霉蛋白酶处理后，所有组分的活性均未改变。
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