Baturin V A, Iuntsev S V
Farmakol Toksikol. 1984 Sep-Oct;47(5):110-3.
The authors studied the ability of neuroleptics to eliminate the amphetamine-induced (5 mg/kg) disorders of the transformation of the defense response trajectory in rats kept in a U-shaped maze. Haloperidol (0.1 mg/kg) and clozapine (2 mg/kg) similarly normalized the animals' behavior but differently affected the motor automatisms typical for amphetamine stereotypy. Metoclopramide (1 mg/kg) reduced the external manifestations of amphetamint stereotypy but did not abolish the disorders in the defense response. It is likely that the ability of the neuroleptics to produce an antiamphetamine action in experimental defense response with multiple transformation of the responses might characterize specific properties of the drugs belonging to the class under discussion.
作者研究了抗精神病药物消除苯丙胺（5毫克/千克）诱导的、处于U型迷宫中的大鼠防御反应轨迹转换障碍的能力。氟哌啶醇（0.1毫克/千克）和氯氮平（2毫克/千克）同样使动物行为正常化，但对苯丙胺刻板行为典型的运动自动症有不同影响。甲氧氯普胺（1毫克/千克）减少了苯丙胺刻板行为的外在表现，但并未消除防御反应中的障碍。在具有多种反应转换的实验性防御反应中，抗精神病药物产生抗苯丙胺作用的能力可能表征了所讨论类别的药物的特定特性。
