Crome P, Vale J A, Volans G N, Widdop B, Goulding R
Lancet. 1976 Oct 16;2(7990):829-30. doi: 10.1016/s0140-6736(76)91211-3.
30 patients at risk of hepatic damage from paracetamol (acetaminophen) ingestion were given 2-5 g oral methionine every four hours up to a total dose of 10 g. The first dose was given within ten hours of the overdose. There were no deaths and no reports of hepatic encephalopathy or other complications. In 21 patients plasma aspartate-aminotransferase remained within normal limits. These results suggest that methionine may be effective in reducing the frequency and severity of paracetamol-induced liver damage and may provide an effective non-toxic alternative to cysteamine.
30名有因摄入对乙酰氨基酚而导致肝损伤风险的患者，每四小时口服2 - 5克蛋氨酸，直至总剂量达到10克。首剂在过量服药后10小时内给予。无死亡病例，也无肝性脑病或其他并发症的报告。21名患者的血浆天冬氨酸氨基转移酶仍在正常范围内。这些结果表明，蛋氨酸可能有效降低对乙酰氨基酚所致肝损伤的发生率和严重程度，并且可能为半胱胺提供一种有效的无毒替代物。
