清醒小牛中，内脏神经刺激后神经肽Y的释放。
Release of neuropeptide Y in response to splanchnic nerve stimulation in the conscious calf.
作者信息
Allen J M, Bircham P M, Bloom S R, Edwards A V
出版信息
J Physiol. 1984 Dec;357:401-8. doi: 10.1113/jphysiol.1984.sp015507.
Abstract
Plasma concentrations of neuropeptide Y were determined by means of a specific radioimmunoassay in the conscious calf. Significantly higher concentrations were found in the adrenal venous effluent (102 +/- 34 pmol/l) compared to systemic arterial plasma (11 +/- 7 pmol/l). Stimulation of the splanchnic nerves at 40 Hz in bursts for 1 s at 10 s intervals resulted in a slow sustained rise in plasma neuropeptide Y in both adrenal (peak 1124 +/- 217 pmol/l and peripheral (peak 771 +/- 182 pmol/l) samples. Experiments performed in adrenalectomized calves produced a closely similar release of neuropeptide Y when the nerves were stimulated intermittently in the same pattern and under the same conditions. Stimulation of the splanchnic nerves at 4 Hz continuously resulted in a smaller response. Pre-treatment with hexamethonium completely abolished the rise in plasma neuropeptide Y concentrations.
摘要
通过特定的放射免疫分析法测定清醒小牛血浆中神经肽Y的浓度。与体循环动脉血浆（11±7 pmol/l）相比，肾上腺静脉流出液中的浓度显著更高（102±34 pmol/l）。以40 Hz的频率、每隔10秒刺激内脏神经1秒，可导致肾上腺样本（峰值1124±217 pmol/l）和外周样本（峰值771±182 pmol/l）中的血浆神经肽Y缓慢持续升高。在肾上腺切除的小牛身上进行的实验表明，当以相同模式和相同条件间歇性刺激神经时，神经肽Y的释放情况非常相似。持续以4 Hz刺激内脏神经会产生较小的反应。六甲铵预处理完全消除了血浆神经肽Y浓度的升高。
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