含有生长激素融合基因的转基因小鼠。
Transgenic mice containing growth hormone fusion genes.
作者信息
Brinster R L, Palmiter R D
出版信息
Philos Trans R Soc Lond B Biol Sci. 1984 Dec 4;307(1132):309-12. doi: 10.1098/rstb.1984.0132.
PMID:6151702
Abstract
New genes composed of the mouse metallothionein I promoter-regulator and the rat or human growth hormone structural gene have been introduced into mice. A large proportion of mice containing these genes express them, and some animals grow to be up to twice as large as controls. The technique has been used in part to correct the genetic defect that results in the small stature of the mutant little mouse.
摘要
由小鼠金属硫蛋白I启动子调控区和大鼠或人类生长激素结构基因组成的新基因已被导入小鼠体内。很大一部分携带这些基因的小鼠表达了它们，一些动物长得比对照动物大两倍。这项技术部分用于纠正导致突变型侏儒小鼠身材矮小的遗传缺陷。
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