Klimov A I, Tikhonova A M, Gorodkova N V, Herrman B, Döhner L, Ghendon Y Z
Acta Virol. 1984 Nov;28(6):479-86.
Comparative studies on the electrophoretic mobility of double-stranded RNA segments constructed of the genome of isolates under study and of reference influenza virus strains of respective serotypes are suggestive for the evolution of majority of the genes of both A and B influenza viruses, including their genes coding for non-glycosylated proteins. Among influenza A and B virus strains which were circulating during the same epidemic, there were variants differing from each other in a number of genes including those coding for virion internal proteins. A recombinant (reassortant) detected among the influenza virus strains, which circulated in Moscow in 1979, contained the genes 4, 6, 7 and 8 identical with those of the reference H1N1 strain, and the genes 1, 2, 3 and 5 identical with those of the reference H3N2 strain. Comparative analysis of reference influenza virus strains, both the H3N2 serotype (being isolated from 1968 to 1979) and the H1N1 serotype (being isolated from 1977 to 1980) differing in the antigenic specificity of their haemagglutinin (HA) suggested the increasing variability of either genes coding for glycoproteins as well as for non-glycosylated proteins.
对所研究分离株基因组构建的双链RNA片段以及各血清型参考流感病毒株的电泳迁移率进行比较研究，提示甲型和乙型流感病毒的大多数基因在进化，包括其编码非糖基化蛋白的基因。在同一流行期间传播的甲型和乙型流感病毒株中，存在一些在包括编码病毒粒子内部蛋白的基因在内的多个基因上彼此不同的变异株。在1979年于莫斯科传播的流感病毒株中检测到的一株重组（重配）病毒，其基因4、6、7和8与参考H1N1株相同，基因1、2、3和5与参考H3N2株相同。对血凝素（HA）抗原特异性不同的参考流感病毒株，即H3N2血清型（1968年至1979年分离）和H1N1血清型（1977年至1980年分离）进行比较分析，提示编码糖蛋白以及非糖基化蛋白的基因变异性均在增加。
