Biddison W E, Ward F E, Shearer G M, Shaw S
J Immunol. 1980 Feb;124(2):548-52.
The self specificity of human influenza virus-immune cytotoxic T cells has been analyzed in order to clarify the relationship between the self antigens that they recognize and the serologically defined HLA-A and -B antigens. Virus-immune effectors from HLA-A2-positive donors were tested on panels of virus-infected target cells from donors who were either HLA-mismatched or matched only for HLA-A2. Virus-immune T cells from 11 out of 11 A2-positive donors lysed all A2-matched virus-infected target cells (and no HLA-mismatched targets), except that each of these effector cells consistently failed to lyse virus-infected target cells from one A2-positive donor (designated M7). Although the A2 specificity of donor M7 could also be distinguished from the A2 antigen of other donors by alloimmune cytotoxic T cells, no differences in the A2 antigen of donor M7 could be defined by extensive serologic analyses. These results indicate that there is a strong but incomplete association between a self antigen recognized by virus-immune T cells and the serologically defined HLA-A2 specificity.
为了阐明人类流感病毒免疫细胞毒性T细胞所识别的自身抗原与血清学定义的HLA - A和 - B抗原之间的关系，对其自身特异性进行了分析。来自HLA - A2阳性供体的病毒免疫效应细胞在来自HLA不匹配或仅与HLA - A2匹配的供体的病毒感染靶细胞组上进行测试。11名HLA - A2阳性供体中的病毒免疫T细胞裂解了所有与A2匹配的病毒感染靶细胞（且未裂解HLA不匹配的靶细胞），但这些效应细胞中的每一个都始终未能裂解来自一名A2阳性供体（称为M7）的病毒感染靶细胞。尽管供体M7的A2特异性也可通过同种免疫细胞毒性T细胞与其他供体的A2抗原区分开来，但通过广泛的血清学分析未发现供体M7的A2抗原有差异。这些结果表明，病毒免疫T细胞识别的自身抗原与血清学定义的HLA - A2特异性之间存在强但不完全的关联。
