Laver W G, Air G M, Dopheide T A, Ward C W
Nature. 1980 Jan 31;283(5746):454-7. doi: 10.1038/283454a0.
Haemagglutinin molecules from nine strains of A/Hong Kong/68 (H3N2) influenza virus, isolated between 1968 and 1977, were examined for changes in amino acid sequences. At least 18 changes, 9 of which were located precisely, occurred in the soluble tryptic peptides of the large haemagglutinin polypeptide (HA1) during this period. These peptides contained 262 residues (82% of HA1). In HA2, only two changes in 129 residues (58% of HA2) were detected. Sequential changes at a particular locus were not found; and as far as we can tell, once an amino acid changed, it did not change again in any subsequent variant examined.
对1968年至1977年间分离出的9株A/香港/68（H3N2）流感病毒的血凝素分子进行了氨基酸序列变化检测。在此期间，大血凝素多肽（HA1）的可溶性胰蛋白酶肽段中至少发生了18处变化，其中9处变化位置精确。这些肽段包含262个残基（占HA1的82%）。在HA2中，仅在129个残基（占HA2的58%）中检测到2处变化。未发现特定位点的连续变化；据我们所知，一旦氨基酸发生变化，在随后检测的任何变体中都不会再次改变。
