Psaila J V, Wheeler M H, Bradley D, Newcombe R
Ann Surg. 1981 Jul;194(1):18-22. doi: 10.1097/00000658-198107000-00004.
The effect of an intravenous infusion of an aminoacid solution (Aminoplex 14) on gastric secretion is compared in healthy subjects and in duodenal ulcer patients. The acid secretory response was twice as high in duodenal ulcer patients than in normal subjects, 60 minutes after starting the infusion. Serum gastrin levels, although initially higher in duodenal ulcer patients, showed no augmentation throughout the infusion. Blood glucose, serum osmolality and PCV estimations did not alter significantly. Serum aminoacid levels showed a pronounced rise, doubling basal values, and tended to parallel the increase in acid output. Cimetidine, administered orally, suppressed the acid secretory response to intravenous aminoacid. The marked stimulation in acid secretion following aminoacid infusion in duodenal ulcer patients was not elicited after truncal or highly selective vagotomy.
在健康受试者和十二指肠溃疡患者中比较了静脉输注氨基酸溶液（Aminoplex 14）对胃液分泌的影响。输注开始60分钟后，十二指肠溃疡患者的胃酸分泌反应比正常受试者高两倍。血清胃泌素水平虽然最初在十二指肠溃疡患者中较高，但在整个输注过程中没有升高。血糖、血清渗透压和红细胞压积测定没有明显变化。血清氨基酸水平显著升高，使基础值翻倍，并倾向于与酸分泌量的增加平行。口服西咪替丁可抑制对静脉输注氨基酸的胃酸分泌反应。在进行迷走神经干切断术或高选择性迷走神经切断术后，十二指肠溃疡患者在输注氨基酸后不会出现明显的胃酸分泌刺激。
